Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,734 questions · 15,288 findings · 893 reviews

No studies found 3,864 · 25.3%GRADE not reported 2,222 · 14.5%Very low 3,868 · 25.3%Low 3,280 · 21.5%Moderate 1,676 · 11%High 378 · 2.5%

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Extraction of the primary (baby) canine (single primary tooth extraction) vs No extraction (non-intervention control)

Number of participants referred for surgical exposure of the PDC · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

It is very uncertain whether extraction of the primary (baby) canine (single primary tooth… changes number of participants referred for surgical exposure of the PDC compared with no extraction (non-intervention control) (very low certainty).

1 finding from 1 review

Hall technique vs Non-restorative cavity control (NRCC)

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…

It is very uncertain whether hall Technique (sealing with a preformed metal crown) changes failure of therapy compared with non-restorative cavity control (NRCC) (very low certainty).

1 finding from 1 review

Non-selective carious tissue removal and conventional restoration (CR) vs Non-restorative cavity control (NRCC)

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…

It is very uncertain whether non-selective carious tissue removal and conventional restoration (CR) changes failure of therapy compared with non-restorative cavity control (NRCC) (very low certainty).

1 finding from 1 review

Sealing using sealant materials vs Non-selective carious tissue removal and conventional restoration (CR)

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…

It is very uncertain whether sealing using sealant materials changes failure of therapy compared with non-selective carious tissue removal and conventional restoration (CR) (very low certainty).

1 finding from 1 review

ARP with allograft plus synthetic cell-binding peptide P-15 vs ARP with allograft without P-15

Aesthetic outcomes of future prosthodontic rehabilitation · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

The review found no eligible studies for this question.

1 finding from 1 review

Sealing using sealant materials vs no treatment

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…

It is very uncertain whether sealing using sealant materials changes failure of therapy compared with no treatment (very low certainty).

1 finding from 1 review

Counter-stimulation and distraction (combined) vs Conventional treatment

Acceptance of LA · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Video modelling acclimatisation vs Acclimatisation in clinic (tell-show-do)

Anxiety · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

Video modelling acclimatisation showed no clear difference in pre- and post-operative anxiety measures (Venham's scale) compared with acclimatisation in clinic (tell-show-do); GRADE not reported.

1 finding from 1 review

Topical triamcinolone acetonide vs pimecrolimus 1%

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in adverse effects compared with topical pimecrolimus; GRADE not reported.

1 finding from 1 review

Clobetasol propionate plus miconazole (adjunctive antifungal) vs Clobetasol propionate plus placebo

Candidosis (adverse effect) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review

General ventilation (e.g. natural ventilation, exhaust fans, opening windows) vs No general ventilation / standard operatory

Outcome not reported · Dental healthcare providers (dentist, dental surgery assistant, dental hygienist, dental technologist, dental laboratory staff, dental…

The review found no eligible studies for this question.

1 finding from 1 review

Topical clobetasol propionate vs Topical ciclosporin

Pain resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical clobetasol propionate changes pain resolution compared with topical ciclosporin (very low certainty).

1 finding from 1 review

Hypnosis vs Conventional treatment

Physical/verbal resistance and self-reported pain during LA (other studies) · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

Hypnosis led to lower physical/verbal resistance and self-reported pain during LA (other… compared with conventional treatment; GRADE not reported.

1 finding from 1 review

High-volume evacuation (HVE) vs No HVE

Reduction in contamination of aerosols on operator's face shield/mask (RCTs) · People undergoing aerosol-generating procedures (AGPs) in a dental setting

High-volume evacuation (HVE) showed no clear difference in reduction in contamination of aerosols on operator's face… compared with no HVE; GRADE not reported.

1 finding from 1 review

Topical clobetasol propionate vs Topical tacrolimus

Pain (mean VAS score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical clobetasol propionate showed no clear difference in pain (mean VAS score) compared with topical tacrolimus; GRADE not reported.

1 finding from 1 review

Topical clobetasol propionate vs Topical tacrolimus

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical clobetasol propionate changes clinical resolution compared with topical tacrolimus (very low certainty).

1 finding from 1 review

Oral prednisone plus curcuminoids (adjunctive) vs Oral prednisone plus placebo

Reduction in pain · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review