Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

657 questions · 681 findings · 36 reviews · Oral and maxillofacial surgery

No studies found 188 · 27.6%GRADE not reported 373 · 54.8%Very low 81 · 11.9%Low 27 · 4%Moderate 8 · 1.2%High 4 · 0.6%

Extraction of the primary maxillary canine vs no intervention

Time to eruption of the permanent canine · Children with palatally displaced maxillary canines (at least 80% aged 10 to 13 years); trials with craniofacial syndromes or anomalies…
1 finding from 1 review

Glucosamine sulfate (oral) vs ibuprofen

Maximum voluntary jaw opening (mm), change from baseline · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Glucosamine sulfate (oral) showed no clear difference in maximum voluntary jaw opening (mm), change from baseline compared with ibuprofen (oral); GRADE not reported.

1 finding from 1 review

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Complications (adverse effects) · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Intra-articular injection of sodium hyaluronate showed no clear difference in complications (adverse effects) compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

1 finding from 1 review

Extraction of the primary maxillary canine vs no intervention

Patient satisfaction and pain experience during extraction of the primary canine · Children with palatally displaced maxillary canines (at least 80% aged 10 to 13 years); trials with craniofacial syndromes or anomalies…

The review found no eligible studies for this question.

1 finding from 1 review

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Presence of TMJ sounds · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Intra-articular injection of sodium hyaluronate led to lower presence of TMJ sounds compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

1 finding from 1 review

Glucosamine sulfate (oral) vs ibuprofen

Extraoral masticatory muscle tenderness (number of tender sites), change from baseline · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Glucosamine sulfate (oral) showed no clear difference in extraoral masticatory muscle tenderness (number of tender sites),… compared with ibuprofen (oral); GRADE not reported.

1 finding from 1 review

Laser therapy

Outcome not reported · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

The review found no eligible studies for this question.

1 finding from 1 review

Oral diclofenac sodium (NSAID) vs splint

Complications (adverse effects) · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Diclofenac sodium (oral NSAID) showed no clear difference in complications (adverse effects) compared with occlusal splint therapy; GRADE not reported.

1 finding from 1 review

Glucosamine sulfate (oral) vs ibuprofen

Reported pain (mm on VAS), change from baseline · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Glucosamine sulfate (oral) showed no clear difference in reported pain (mm on VAS), change from baseline compared with ibuprofen (oral); GRADE not reported.

1 finding from 1 review

Glucosamine sulfate (oral) vs ibuprofen

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Glucosamine sulfate (oral) showed no clear difference in brief Pain Inventory (BPI) - pain intensity, change from baseline compared with ibuprofen (oral); GRADE not reported.

1 finding from 1 review

Extraction of the primary maxillary canine plus cervical pull headgear vs no intervention

Prevalence of eruption/non-eruption of the palatally displaced permanent canine (successful eruption) · Children with palatally displaced maxillary canines (at least 80% aged 10 to 13 years); trials with craniofacial syndromes or anomalies…
1 finding from 1 review

Extraction of the primary maxillary canine vs no intervention

Incidence or prevalence of root resorption of the impacted canine and/or incisors and cyst formation · Children with palatally displaced maxillary canines (at least 80% aged 10 to 13 years); trials with craniofacial syndromes or anomalies…

The review found no eligible studies for this question.

1 finding from 1 review

Extraction of the primary maxillary canine vs no intervention

Improvement in the vertical position or angulation of the ectopic canine, measured from radiographs · Children with palatally displaced maxillary canines (at least 80% aged 10 to 13 years); trials with craniofacial syndromes or anomalies…
1 finding from 1 review

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Pain on palpation of the affected/contralateral TMJ and masticatory muscles · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Intra-articular injection of sodium hyaluronate led to lower pain on palpation of the affected/contralateral TMJ and masticatory… compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

1 finding from 1 review
  • Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
    14 days to 6 months
    Pain on palpation of the affected and contralateral TMJ and masticatory muscles presented similar frequencies regardless of the time (Analyses 1.4-1.12); no statistically significant differences reported. Point…
    1 study · 40 participants
    GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Extent of mandibular movement (maximum jaw opening, lateral and contralateral movement, jaw protrusion) · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Intra-articular injection of sodium hyaluronate showed no clear difference in extent of mandibular movement (maximum jaw opening, lateral and… compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

1 finding from 1 review
  • Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
    14 days to 6 months
    None of the mean differences between interventions for the measures of jaw movements (maximum jaw opening, lateral movement to affected side, contralateral movement, jaw protrusion; Analyses 1.16-1.27) showed…
    1 study · 40 participants
    GRADE not reported

Reassurance / behavioral management (control of contributory factors)

Outcome not reported · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

The review found no eligible studies for this question.

1 finding from 1 review

Glucosamine sulfate (oral) vs ibuprofen

Pain-free maximum jaw opening (mm), change from baseline · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Glucosamine sulfate (oral) showed no clear difference in pain-free maximum jaw opening (mm), change from baseline compared with ibuprofen (oral); GRADE not reported.

1 finding from 1 review

Extraction of the primary maxillary canine plus cervical pull headgear vs Extraction of the primary maxillary canine alone

Prevalence of eruption/non-eruption of the palatally displaced permanent canine (successful eruption) · Children with palatally displaced maxillary canines (at least 80% aged 10 to 13 years); trials with craniofacial syndromes or anomalies…
1 finding from 1 review

Arthrocentesis

Outcome not reported · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

The review found no eligible studies for this question.

1 finding from 1 review