Pregabalin vs active comparators
Pregabalin showed no clear difference in treatment withdrawal for any reason compared with active comparators (low certainty).
- RR 0.93 [0.76, 1.13]3 studies · 1286 participantsLow
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Pregabalin showed no clear difference in treatment withdrawal for any reason compared with active comparators (low certainty).
Pregabalin probably leads to higher treatment withdrawal for any reason compared with placebo (moderate certainty).
Pregabalin probably leads to higher treatment withdrawal due to adverse effects compared with placebo (moderate certainty).
Pregabalin may leads to higher adverse effect: ataxia compared with placebo (low certainty).
Pregabalin may leads to higher adverse effect: dizziness compared with placebo (low certainty).
Pregabalin showed no clear difference in adverse effect: fatigue compared with placebo (low certainty).
One study found space closure more likely with crowding than spacing (OR 5.9; single study; not GRADE-rated).
It is very uncertain whether prednisone plus azathioprine changes disease control (at 6 months) compared with prednisone (very low certainty).
It is very uncertain whether prednisone plus azathioprine changes mortality (at 6 months) compared with prednisone (very low certainty).
The review found no eligible studies for this question.