Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

866 questions · 900 findings · 80 reviews

No studies found 198 · 22%GRADE not reported 207 · 23%Very low 158 · 17.6%Low 211 · 23.4%Moderate 98 · 10.9%High 28 · 3.1%

Repair of a defective resin composite restoration in a permanent molar or premolar tooth (with resin composite) vs Replacement of a defective resin composite restoration in a permanent molar or premolar tooth (with resin composite)

Extraction of tooth (due to decay) · Adults (16 years or over) with one or more defective resin composite restoration(s) in a molar or premolar tooth/teeth

The review found no eligible studies for this question.

1 finding from 1 review

Repair of a defective amalgam restoration in a permanent molar or premolar tooth (with amalgam) vs Replacement of a defective amalgam restoration in a permanent molar or premolar tooth (with amalgam)

Presence of clinical symptoms (pain, swelling, diagnosis of pulpitis, abscess formation) · Adults (16 years or over) with one or more defective amalgam restoration(s) in a molar or premolar tooth/teeth

The review found no eligible studies for this question.

1 finding from 1 review

Repair of a defective amalgam restoration in a permanent molar or premolar tooth (with amalgam) vs Replacement of a defective amalgam restoration in a permanent molar or premolar tooth (with amalgam)

Further restoration required (repair, restoration, placement of crown/inlay, root filling) · Adults (16 years or over) with one or more defective amalgam restoration(s) in a molar or premolar tooth/teeth

The review found no eligible studies for this question.

1 finding from 1 review

Repair of a defective resin composite restoration in a permanent molar or premolar tooth (with resin composite) vs Replacement of a defective resin composite restoration in a permanent molar or premolar tooth (with resin composite)

Patient satisfaction (measured by patient satisfaction or aesthetic scales) · Adults (16 years or over) with one or more defective resin composite restoration(s) in a molar or premolar tooth/teeth

The review found no eligible studies for this question.

1 finding from 1 review

Primary analysis: less vs more frequent

Catheter‐related BSI as defined using criteria specified by Maki 2006; Mermel 2009; and O'Grady 2002 · patients with intravenous administration set replacement

Primary analysis: less showed no clear difference in catheter‐related BSI as defined using criteria specified by Maki… compared with more frequent (low certainty).

1 finding from 1 review

Primary analysis: less vs more frequent

Infusate‐related BSI as defined using criteria specified by O'Grady 2002 · patients with intravenous administration set replacement

Primary analysis: less showed no clear difference in infusate‐related BSI as defined using criteria specified by O'Grady… compared with more frequent (low certainty).

1 finding from 1 review

Primary analysis: less vs more frequent

Infusate colonization any positive quantitative culture of infusate · patients with intravenous administration set replacement

Primary analysis: less showed no clear difference in infusate colonization any positive quantitative culture of infusate compared with more frequent (low certainty).

1 finding from 1 review

Primary analysis: less vs more frequent

Catheter colonization any positive semiquantitative or quantitative culture from the distal catheter segment · patients with intravenous administration set replacement

Primary analysis: less showed no clear difference in catheter colonization any positive semiquantitative or quantitative… compared with more frequent (moderate certainty).

1 finding from 1 review

Primary analysis: less vs more frequent

All‐cause BSI any positive blood culture drawn from a peripheral vein taken whilst the IVD is in situ, or within 48 hours of removal (O'Grady 2002) · patients with intravenous administration set replacement

Primary analysis: less showed no clear difference in all‐cause BSI any positive blood culture drawn from a peripheral… compared with more frequent (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs low molecular weight heparin

Major VTE events bilateral ascending venography1 · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in major VTE events bilateral ascending venography1 compared with low molecular weight heparins (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs low molecular weight heparin

All‐cause Mortality events · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors probably leads to higher all‐cause Mortality events compared with low molecular weight heparins (moderate certainty).

1 finding from 1 review

Direct thrombin inhibitors vs low molecular weight heparin

Total Bleeding events · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in total Bleeding events compared with low molecular weight heparins (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs low molecular weight heparin

ALT >3 times the upper normal limit · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors may leads to lower ALT >3 times the upper normal limit compared with low molecular weight heparins (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs vitamin K antagonist (VKA)

Major VTE events in TKR combined doses bilateral ascending venography · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in major VTE events in TKR combined doses bilateral ascending venography compared with vitamin K antagonists (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs vitamin K antagonist (VKA)

All‐cause Mortality events in TKR combined doses · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in all‐cause Mortality events in TKR combined doses compared with vitamin K antagonists (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs vitamin K antagonist (VKA)

Total Bleeding events in TKR combined doses · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in total Bleeding events in TKR combined doses compared with vitamin K antagonists (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs vitamin K antagonist (VKA)

ALT >3 times the upper normal limit · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in ALT >3 times the upper normal limit at the end of compared with vitamin K antagonists (low certainty).

1 finding from 1 review