Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

493 questions · 509 findings · 56 reviews · Headline outcomes only

No studies found 149 · 29.3%GRADE not reported 9 · 1.8%Very low 128 · 25.1%Low 123 · 24.2%Moderate 79 · 15.5%High 21 · 4.1%

Distal splenorenal shunt vs endoscopic intervention

All‐cause mortality · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether distal splenorenal shunt changes all‐cause mortality compared with endoscopic intervention (very low certainty).

1 finding from 1 review

Distal splenorenal shunt vs endoscopic intervention

Rebleeding · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether distal splenorenal shunt changes rebleeding compared with endoscopic intervention (very low certainty).

1 finding from 1 review

Distal splenorenal shunt vs endoscopic intervention

Mortality due to rebleeding · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether distal splenorenal shunt changes mortality due to rebleeding compared with endoscopic intervention (very low certainty).

1 finding from 1 review

Distal splenorenal shunt vs endoscopic intervention

Acute hepatic encephalopathy · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether distal splenorenal shunt changes acute hepatic encephalopathy compared with endoscopic intervention (very low certainty).

1 finding from 1 review

Distal splenorenal shunt vs endoscopic intervention

Chronic hepatic encephalopathy · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether distal splenorenal shunt changes chronic hepatic encephalopathy compared with endoscopic intervention (very low certainty).

1 finding from 1 review

Total shunt vs endoscopic intervention

All‐cause mortality · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether total shunt changes all‐cause mortality compared with endoscopic intervention (very low certainty).

1 finding from 1 review

Vaginal misoprostol vs placebo

Opiate use (as a proxy measure for pain) for all participants on ITT (including those without confirmed AMI) · early fetal death (less than 24 weeks)

It is very uncertain whether vaginal misoprostol changes pain (opiate use) compared with placebo (very low certainty).

1 finding from 1 review