Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

728 questions · 764 findings · 107 reviews

No studies found 194 · 25.4%GRADE not reported 47 · 6.2%Very low 212 · 27.7%Low 194 · 25.4%Moderate 99 · 13%High 18 · 2.4%

Multiple vs single‐injection technique

Secondary analgesia failure: Intraoperative sedation required · Adult patients undergoing hand, wrist or forearm surgery

Multiple showed no clear difference in secondary analgesia failure ‐ intraoperative sedation required compared with single‐injection technique (high certainty).

1 finding from 1 review

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Live birth rate per woman · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

It is very uncertain whether day 3 changes live birth rate per woman compared with day 2 embryo transfer following IVF or ICSI (very low certainty).

1 finding from 1 review

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Ongoing pregnancy · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

It is very uncertain whether day 3 changes ongoing pregnancy rate per woman compared with day 2 embryo transfer following IVF or ICSI (very low certainty).

1 finding from 1 review

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Clinical pregnancy rate · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

It is very uncertain whether day 3 changes clinical pregnancy rate per woman compared with day 2 embryo transfer following IVF or ICSI (very low certainty).

1 finding from 1 review

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Multiple pregnancy rate · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

Day 3 showed no clear difference in multiple pregnancy rate per woman compared with day 2 embryo transfer following IVF or ICSI (moderate certainty).

1 finding from 1 review

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Miscarriage · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

Day 3 showed no clear difference in miscarriage rate per woman compared with day 2 embryo transfer following IVF or ICSI (moderate certainty).

1 finding from 1 review

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Complications during pregnancy per woman per couple ‐ ectopic pregnancy4 · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

Day 3 showed no clear difference in ectopic pregnancy rate per woman compared with day 2 embryo transfer following IVF or ICSI (low certainty).

1 finding from 1 review