What do systematic reviews say?

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Intervention not reported

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 70 participants
  GRADE not reported

Intervention not reported

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 70 participants
  GRADE not reported

Intra‐arterial delivery vs intravenous delivery

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 78 participants
  Low

High‐dose vs low‐dose regimens of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 302 participants
  Very low

Intervention not reported

The intervention probably leads to lower presence of PDA on third to fourth day of life (after 72 hours of… (moderate certainty).

• Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants 2020 · Cochrane Headline outcomes only
  RR 0.39 [0.31, 0.48]
  9 studies · 1029 participants
  Moderate

Intervention not reported

• Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 827 participants
  High

Intervention not reported

The intervention probably leads to lower incidence of AAD: Probiotic dose (≥5 billion CFUs of probiotics/day) (moderate certainty).

• Probiotics for the prevention of pediatric antibiotic‐associated diarrhea 2019 · Cochrane Headline outcomes only
  RR 0.37 [0.3, 0.46]
  20 studies · 4038 participants
  Moderate

Intervention not reported

• Probiotics for the prevention of pediatric antibiotic‐associated diarrhea 2019 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 1263 participants
  Low

Effects of clinically‐indicated replacement vs routine change of peripheral intravenous catheters

Effects of clinically‐indicated replacement showed no clear difference in thrombophlebitis (per device days) (during hospitalisation) compared with routine change of peripheral intravenous catheters (moderate certainty).

• Clinically‐indicated replacement versus routine replacement of peripheral venous catheters 2019 · Cochrane Headline outcomes only
  RR 0.9 [0.76, 1.08]
  6 studies · 32709 participants
  Moderate

Chest physiotherapy vs no chest physiotherapy

Chest physiotherapy showed no clear difference in duration of hospital stay (days) ( compared with no chest physiotherapy (low certainty).

• Chest physiotherapy for pneumonia in children 2019 · Cochrane Headline outcomes only
  MD 0.1
  4 studies · 415 participants
  Low

Perioperative alcohol cessation intervention vs treatment

Perioperative alcohol cessation intervention showed no clear difference in in‐hospital and 30‐day mortality compared with treatment (low certainty).

• Perioperative alcohol cessation intervention for postoperative complications 2018 · Cochrane Headline outcomes only
  RR 0.47 [0.07, 2.96]
  3 studies · 122 participants
  Low

Other prokinetics vs domperidone

It is very uncertain whether other prokinetics changes not symptom‐free or no symptoms improvement (itopride 50 three times… compared with domperidone 10mg three times a day (very low certainty).

• Prokinetics for functional dyspepsia 2018 · Cochrane Headline outcomes only
  RR 0.94 [0.83, 1.07]
  7 studies · 1527 participants
  Very low

HALOPERIDOL vs placebo

Haloperidol showed no clear difference in the event rate of intensive care delirium within 28 days. compared with placebo (moderate certainty).

• Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
  RR 1.01 [0.87, 1.17]
  1 study · 1439 participants
  Moderate

HALOPERIDOL vs placebo

Haloperidol showed no clear difference in in‐hospital mortality within 28 days. compared with placebo (moderate certainty).

• Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
  RR 0.98 [0.8, 1.22]
  2 studies · 1580 participants
  Moderate

HALOPERIDOL vs placebo

• Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1580 participants
  Moderate

HALOPERIDOL vs placebo

• Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1439 participants
  High

HALOPERIDOL vs placebo

• Interventions for preventing intensive care unit delirium in adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1580 participants
  High

Day care programs combined with playpen provision vs playpen provision

It is very uncertain whether day care programs combined with playpen provision changes drowning mortality rate compared with playpen provision (very low certainty).

• Day care as a strategy for drowning prevention in children under 6 years of age in low‐ and middle‐income countries 2021 · Cochrane Headline outcomes only
  Rate ratio 0.06 [0.02, 0.12]
  1 study · 45460 participants
  Very low