Findings

What do systematic reviews say?

4,771 questions · 10,185 findings · 893 reviews

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No studies found 2,109 · 20.7%GRADE not reported 1,125 · 11%Very low 2,279 · 22.4%Low 2,514 · 24.7%Moderate 1,709 · 16.8%High 449 · 4.4%

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Intervention not reported

Dropouts ‐ not measured · dementia

The review found no eligible studies for this question.

1 finding from 1 review

Simulated presence therapy for dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Final height and change in height · people with thalassaemia (any age)

The review found no eligible studies for this question.

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Adverse effects Oral glucose tolerance test (mg/dL) (at one year) · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Height SDS(at one year) · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Change in height SDS (difference between baseline and final visit at one year) · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Height velocity (cm/year) · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Height velocity SDS · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Change in height velocity SDS (difference between baseline and final visit at one year) · people with thalassaemia (any age)

1 finding from 1 review

Growth hormone therapy for people with thalassaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Citrate vs unfractionated heparin

Major bleeding · CRRT

Citrate probably leads to lower major bleeding compared with unfractionated heparin (moderate certainty).

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
RR 0.22 [0.08, 0.62]
7 studies · 535 participants
Moderate

Unfractionated heparin vs low molecular weight heparin

Successful prevention of clotting · CRRT

It is very uncertain whether unfractionated heparin changes successful prevention of clotting compared with low molecular weight heparin (very low certainty).

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
RR 0.95 [0.7, 1.31]
1 study · 54 participants
Very low

Unfractionated heparin vs low molecular weight heparin

Treatment cessation due to adverse events · CRRT

Unfractionated heparin showed no clear difference in treatment cessation due to adverse events compared with low molecular weight heparin (low certainty).

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
RR 0.29 [0.02, 3.53]
2 studies · 77 participants
Low

Unfractionated heparin vs low molecular weight heparin

Recovery of kidney function · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Unfractionated heparin vs low molecular weight heparin

Thrombocytopenia · CRRT

It is very uncertain whether unfractionated heparin changes thrombocytopenia compared with low molecular weight heparin (very low certainty).

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
RR 0.57 [0.2, 1.63]
2 studies · 124 participants
Very low

Unfractionated heparin vs low molecular weight heparin

Cost to health care services · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Unfractionated heparin vs no pharmacological anticoagulation

Major bleeding · CRRT

It is very uncertain whether unfractionated heparin changes major bleeding compared with no pharmacological anticoagulation (very low certainty).

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
RR 0.5 [0.05, 4.67]
1 study · 10 participants
Very low

Unfractionated heparin vs no pharmacological anticoagulation

Death at 28 days · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Unfractionated heparin vs no pharmacological anticoagulation

Successful prevention of clotting · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Unfractionated heparin vs no pharmacological anticoagulation

Treatment cessation due to adverse events · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Unfractionated heparin vs no pharmacological anticoagulation

Recovery of kidney function · CRRT

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Citrate vs unfractionated heparin

Death at 28 days · CRRT

Citrate showed no clear difference in death at 28 days compared with unfractionated heparin (moderate certainty).

1 finding from 1 review

Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
RR 1.06 [0.86, 1.3]
5 studies · 462 participants
Moderate