Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,678 questions · 4,859 findings · 283 reviews

No studies found 1,225 · 25.2%GRADE not reported 215 · 4.4%Very low 1,241 · 25.5%Low 1,210 · 24.9%Moderate 776 · 16%High 192 · 4%

Summary of findings 1: Efficacy and safety of IVT lampalizumab 4‐weekly (monthly) vs sham

Safety: Development of macular neovascularisation or exudative AMD at 1 year · adults with GA due to AMD

Summary of findings 1: Efficacy and safety of IVT lampalizumab… showed no clear difference in safety: Development of macular neovascularisation or exudative AMD… compared with sham (low certainty).

1 finding from 1 review

Summary of findings 1: Efficacy and safety of IVT lampalizumab 4‐weekly (monthly) vs sham

Safety: Development of endophthalmitis at 1 year · adults with GA due to AMD

Summary of findings 1: Efficacy and safety of IVT lampalizumab… showed no clear difference in safety: Development of endophthalmitis at 1 year compared with sham (moderate certainty).

1 finding from 1 review

Summary of findings 1: Efficacy and safety of IVT lampalizumab 4‐weekly (monthly) vs sham

Loss of ≥ 15 letters BCVA at 1 year · adults with GA due to AMD

Summary of findings 1: Efficacy and safety of IVT lampalizumab… showed no clear difference in loss of ≥ 15 letters BCVA at 1 year compared with sham (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Starting short‐term prophylactic dose anticoagulation vs avoiding anticoagulation

Death · survivors of stroke due to intracerebral haemorrhage

It is very uncertain whether summary of findings table ‐ Starting short‐term prophylactic dose… changes death compared with avoiding anticoagulation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Starting short‐term prophylactic dose anticoagulation vs avoiding anticoagulation

Venous thromboembolism · survivors of stroke due to intracerebral haemorrhage

It is very uncertain whether summary of findings table ‐ Starting short‐term prophylactic dose… changes venous thromboembolism compared with avoiding anticoagulation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Starting short‐term prophylactic dose anticoagulation vs avoiding anticoagulation

Intracerebral haemorrhage (ICH) · survivors of stroke due to intracerebral haemorrhage

It is very uncertain whether summary of findings table ‐ Starting short‐term prophylactic dose… changes intracerebral haemorrhage (ICH) compared with avoiding anticoagulation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Starting short‐term prophylactic dose anticoagulation vs avoiding anticoagulation

Functional status: mRS 0‐2 · survivors of stroke due to intracerebral haemorrhage

It is very uncertain whether summary of findings table ‐ Starting short‐term prophylactic dose… changes functional status: mRS 0‐2 compared with avoiding anticoagulation (very low certainty).

1 finding from 1 review