Findings

What do systematic reviews say?

603 questions · 627 findings · 69 reviews · Pain, Palliative and Supportive Care

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No studies found 111 · 17.7%GRADE not reported 27 · 4.3%Very low 191 · 30.5%Low 138 · 22%Moderate 100 · 15.9%High 60 · 9.6%

Morphine vs placebo

At least 50% reduction in pain · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
62 participants
Very low

Morphine vs placebo

Patient Global Impression of Change much or very much improved · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Very low

Morphine vs placebo

Any pain‐related outcome (moderate pain improvement) · adults with neuropathic pain

It is very uncertain whether morphine changes any pain‐related outcome (moderate pain improvement) compared with placebo (very low certainty).

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
RD 0.27 [0.16, 0.38]
4 studies · 263 participants
Very low

Morphine vs placebo

Serious adverse events · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 289 participants
Very low

Morphine vs placebo

Death · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 289 participants
Very low

Morphine vs placebo

Any adverse event · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 289 participants
Very low

Morphine vs placebo

Withdrawal (all‐cause) · adults with neuropathic pain

It is very uncertain whether morphine changes all‐cause withdrawal compared with placebo (very low certainty).

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
RD 0.04
4 studies · 289 participants
Very low

Aspirin 1000 mg vs placebo

Pain‐free at 2 hours · adults with episodic tension‐type headache

1 finding from 1 review

Aspirin for acute treatment of episodic tension‐type headache in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Aspirin 1000 mg vs placebo

Pain‐free at different time points (1, 4, 24 hours) · adults with episodic tension‐type headache

1 finding from 1 review

Aspirin for acute treatment of episodic tension‐type headache in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Aspirin 1000 mg vs placebo

Pain‐free or mild pain at 2 hours · adults with episodic tension‐type headache

1 finding from 1 review

Aspirin for acute treatment of episodic tension‐type headache in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 215 participants
Very low

Aspirin 1000 mg vs placebo

Use of rescue medication · adults with episodic tension‐type headache

1 finding from 1 review

Aspirin for acute treatment of episodic tension‐type headache in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 397 participants
Low

Aspirin 1000 mg vs placebo

Patient Global Evaluation at end of study · adults with episodic tension‐type headache

1 finding from 1 review

Aspirin for acute treatment of episodic tension‐type headache in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 397 participants
Very low

Aspirin 1000 mg vs placebo

Any adverse event · adults with episodic tension‐type headache

1 finding from 1 review

Aspirin for acute treatment of episodic tension‐type headache in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 723 participants
Low

Aspirin 1000 mg vs placebo

Specific adverse events · adults with episodic tension‐type headache

1 finding from 1 review

Aspirin for acute treatment of episodic tension‐type headache in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 767 participants
Very low

Aspirin 1000 mg vs placebo

Serious adverse events · adults with episodic tension‐type headache

1 finding from 1 review

Aspirin for acute treatment of episodic tension‐type headache in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 767 participants
Very low

Dexamethasone vs placebo

Nausea · participants with advanced cancer who have nausea and vomiting not related to chemotherapy, radiotherapy, or surgery

1 finding from 1 review

Corticosteroids for adult patients with advanced cancer who have nausea and vomiting (not related to chemotherapy,… 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 127 participants
Very low

Dexamethasone vs placebo

Number of vomiting episodes · participants with advanced cancer who have nausea and vomiting not related to chemotherapy, radiotherapy, or surgery

The review found no eligible studies for this question.

1 finding from 1 review

Corticosteroids for adult patients with advanced cancer who have nausea and vomiting (not related to chemotherapy,… 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Dexamethasone vs placebo

Adverse events · participants with advanced cancer who have nausea and vomiting not related to chemotherapy, radiotherapy, or surgery

The review found no eligible studies for this question.

1 finding from 1 review

Corticosteroids for adult patients with advanced cancer who have nausea and vomiting (not related to chemotherapy,… 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Dexamethasone vs placebo

Quality of life · participants with advanced cancer who have nausea and vomiting not related to chemotherapy, radiotherapy, or surgery

The review found no eligible studies for this question.

1 finding from 1 review

Corticosteroids for adult patients with advanced cancer who have nausea and vomiting (not related to chemotherapy,… 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Dexamethasone vs placebo

Patient satisfaction · participants with advanced cancer who have nausea and vomiting not related to chemotherapy, radiotherapy, or surgery

The review found no eligible studies for this question.

1 finding from 1 review

Corticosteroids for adult patients with advanced cancer who have nausea and vomiting (not related to chemotherapy,… 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found