Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

681 questions · 709 findings · 179 reviews

No studies found 180 · 25.4%GRADE not reported 51 · 7.2%Very low 194 · 27.4%Low 144 · 20.3%Moderate 110 · 15.5%High 30 · 4.2%

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

Secondary outcome: acceptability of treatment · depression in adults

It is very uncertain whether S‐adenosyl methionine as monotherapy changes acceptability Participants dropping out of treatment during the… compared with tricyclic antidepressant agent (very low certainty).

1 finding from 1 review

Fluoride mouthrinse (any fluoride agent, concentration, volume, frequency or technique; swished and expectorated, not swallowed) vs placebo or no treatment

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

It is very uncertain whether fluoride mouthrinse (any fluoride agent, concentration, volume,… changes unacceptability of treatment as measured by leaving study early… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Unacceptability of treatment (dropouts/exclusions during the trial) · Children and adolescents aged 16 years or less

Fluoride gel (topically applied; operator- or self-applied; any… showed no clear difference in unacceptability of treatment (dropouts/exclusions during the trial) compared with placebo or no treatment; GRADE not reported.

3 findings from 1 review

Rivastigmine vs placebo

Acceptability · Apathy in people with mild‐to‐moderate Alzheimer's disease

Rivastigmine probably leads to higher acceptability of treatment (as measured by withdrawals from trials… compared with placebo (moderate certainty).

1 finding from 1 review

Lithium as sole treatment vs placebo

Acceptability ‐ total dropouts · schizophrenia

Lithium as sole treatment showed no clear difference in acceptability of treatment leaving early due to any reason compared with placebo (low certainty).

1 finding from 1 review

Lithium vs antipsychotics

Acceptability ‐ total dropouts · schizophrenia

It is very uncertain whether lithium changes acceptability of treatment leaving early due to any reason compared with antipsychotics (very low certainty).

1 finding from 1 review

Paroxetine vs placebo

Secondary outcome: acceptability of treatment · people with anxiety and comorbid alcohol use disorders

It is very uncertain whether paroxetine changes treatment acceptability compared with placebo (very low certainty).

1 finding from 1 review

DCS and cognitive and behavioural therapies vs placebo and cognitive and behavioural therapies

Treatment withdrawal · adults with anxiety disorders

DCS and cognitive and behavioural therapies showed no clear difference in treatment acceptability: withdrawals from treatment compared with placebo and cognitive and behavioural therapies (moderate certainty).

1 finding from 1 review

DCS and cognitive and behavioural therapies vs placebo and cognitive and behavioural therapies

Treatment withdrawal · children and adolescents with anxiety disorders

It is very uncertain whether DCS and cognitive and behavioural therapies changes treatment acceptability: withdrawals from treatment compared with placebo and cognitive and behavioural therapies (very low certainty).

1 finding from 1 review

Morita therapy plus pharmacological therapy vs Pharmacological therapy

Secondary outcome: acceptability of treatment · patients with anxiety disorders

It is very uncertain whether morita therapy plus pharmacological therapy changes acceptability drop‐outs for any reason compared with pharmacological therapy alone (very low certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Behaviour: Leaving the study early (short‐term) · patients with schizophrenia

Haloperidol showed no clear difference in leaving the study early due to any reason as a measure of overall… compared with first‐generation antipsychotics (low certainty).

1 finding from 1 review