Angular cheilitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No eligible studies compared angular cheilitis between different ART regimens.
1 finding from 1 review
Dental caries prevalence · Children or adolescents
In permanent dentition, CLWH on ART had higher caries prevalence than healthy controls (OR 2.49, 95% CI 1.86 to 3.32; single study).
3 findings from 1 review
Oral Health Status of Children and Adolescents Living with HIV Undergoing Antiretroviral Therapy: A Systematic Review… 2022 All outcomesCross-sectional (case-control; single time point) · HIV pediatric/ART clinics, AIDS centers, and hospitals in Brazil, India, Saudi Arabia, and West Africa (Cote d'Ivoire, Mali, Senegal) · Permanent dentition (DMFT > 0)
OR 2.49 [1.86, 3.32]
1 study · 724 participants
GRADE not reported
Oral Health Status of Children and Adolescents Living with HIV Undergoing Antiretroviral Therapy: A Systematic Review… 2022 All outcomesCross-sectional (case-control; single time point) · HIV pediatric/ART clinics, AIDS centers, and hospitals in Brazil, India, Saudi Arabia, and West Africa (Cote d'Ivoire, Mali, Senegal)
OR 2.70 [2.01, 3.62]
2 studies · 1028 participants
GRADE not reported
Oral Health Status of Children and Adolescents Living with HIV Undergoing Antiretroviral Therapy: A Systematic Review… 2022 All outcomesCross-sectional (case-control; single time point) · HIV pediatric/ART clinics, AIDS centers, and hospitals in Brazil, India, Saudi Arabia, and West Africa (Cote d'Ivoire, Mali, Senegal) · Primary dentition (dmft > 0)
OR 1.93 [1.34, 2.79]
1 study · 564 participants
GRADE not reported
Plaque · Adults and children (predominantly adults; one study in children), with natural dentition
Sugar-free chewing gum significantly reduced plaque quantity versus no-gum/control (SMD -0.778, 95% CI -1.167 to -0.390), with high heterogeneity (I2 = 86.6%) and no GRADE rating (ungraded).
2 findings from 1 review
Mucocele · Children or adolescents
No significant difference in mucocele between groups (OR 3.03, 95% CI 0.12 to 75.37; single study).
1 finding from 1 review
Mucocele prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in mucocele between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 0.02 [0.00, 1.09]
Studies not reported
Very low
Dental development and maturation · Children and adolescents (<18 years) living with HIV (CLWH)
No eligible studies compared dental development and maturation between different ART regimens.
1 finding from 1 review
Angular cheilitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in angular cheilitis between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 0.58 [0.17, 1.99]
Studies not reported
Very low
Ulcerative stomatitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Ulcerative stomatitis was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).
1 finding from 1 review
OR 0.03 [0.02, 0.07]
Studies not reported
Very low
Acute necrotizing ulcerative gingivitis/periodontitis (WHO clinical stage 3) · Children or adolescents
No eligible studies reported acute necrotizing ulcerative gingivitis/periodontitis.
1 finding from 1 review
Chronic herpes simplex infection (WHO clinical stage 4) · Children or adolescents
No eligible studies reported chronic herpes simplex infection.
1 finding from 1 review
Acute necrotising ulcerative periodontitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in acute necrotising ulcerative periodontitis between ART regimens (very low certainty).
1 finding from 1 review
Periodontal disease prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
ART was not associated with a significant difference in periodontal disease prevalence among CLWH (very low certainty).
1 finding from 1 review
Kaposi's sarcoma prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Kaposi's sarcoma was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).
1 finding from 1 review
OR 0.00 [0.00, 0.03]
Studies not reported
Very low
Kaposi's sarcoma prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in kaposi's sarcoma between ART regimens (very low certainty).
1 finding from 1 review
Linear gingival erythema prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in linear gingival erythema between ART regimens (very low certainty).
1 finding from 1 review
Persistent parotid enlargement (WHO clinical stage 2) · Children or adolescents
No significant difference in persistent parotid enlargement between groups (OR 10.36, 95% CI 0.53 to 201.45; single study, very imprecise).
1 finding from 1 review
Chronic herpes simplex infection prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in chronic herpes simplex infection between ART regimens (very low certainty).
1 finding from 1 review
Angular cheilitis (WHO clinical stage 2) · Children or adolescents
No significant difference in angular cheilitis prevalence between CLWH and healthy controls (pooled OR 1.95, 95% CI 0.16 to 23.65).
1 finding from 1 review
Mucosal hyperpigmentation prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in mucosal hyperpigmentation between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 1.79 [0.89, 3.61]
Studies not reported
Very low
Gingivitis · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in gingivitis between ART regimens (very low certainty).
1 finding from 1 review