Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,271 questions · 1,326 findings · 329 reviews

No studies found 247 · 18.6%GRADE not reported 237 · 17.9%Very low 379 · 28.6%Low 285 · 21.5%Moderate 141 · 10.6%High 37 · 2.8%

Summary of findings: bevacizumab vs ranibizumab

BCVA: gain of 15 or more ETDRS letters · people with neovascular age‐related macular degeneration

Summary of findings: bevacizumab showed no clear difference in gain of 15 or more letters visual acuity at 1 year compared with ranibizumab (high certainty).

1 finding from 1 review

Intervention not reported

Infusion‐related reactions (number of participants with one or more reaction) · adults and children with mucopolysaccharidosis I

The intervention showed no clear difference in infusion‐related reactions (number of participants with one or more… (low certainty).

1 finding from 1 review

Surgery with excision of failed tape vs surgery without excision of tape

Objective cure rates in the longer‐term ‐ more than 12 months, · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

Repeat midurethral tape (any type) vs any other non‐tape surgical treatment (e.g. traditional sling, colposuspension, injectables)

Objective cure rates in the longer‐term ‐ more than 12 months, · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

One type of repeat midurethral tape vs another type of repeat midurethral tape

Objective cure rates in the longer‐term ‐ more than 12 months, · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

Sulthiame add‐on vs placebo

Number experiencing adverse effects · patients between 3 to 15 months of age with West syndrome

It is very uncertain whether sulthiame add‐on changes adverse effects: total number of participants experiencing one or… compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Achievement of at least 50% reduction in headache severity Post‐treatment Higher scores indicate more children with reduced headache · children or adolescents with headaches

It is very uncertain whether the intervention changes achievement of at least 50% reduction in headache severity… (very low certainty).

1 finding from 1 review