Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,411 questions · 1,474 findings · 170 reviews

No studies found 336 · 22.8%GRADE not reported 97 · 6.6%Very low 419 · 28.4%Low 395 · 26.8%Moderate 188 · 12.8%High 39 · 2.6%

Portosystemic shunts vs endoscopic intervention with or without medical treatment

Chronic hepatic encephalopathy · participants with cirrhosis and with previous oesophagogastric variceal bleeding

It is very uncertain whether portosystemic shunts changes chronic hepatic encephalopathy compared with endoscopic intervention with or without medical treatment (very low certainty).

1 finding from 1 review

GnRHa treatment vs other medical therapies before any surgery

Preoperative bleeding: (PBAC < 75) ulipristal acetate 5 mg · women with uterine fibroids

GnRHa treatment showed no clear difference in preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal… compared with other medical therapies before any surgery (moderate certainty).

1 finding from 1 review

GnRHa treatment vs other medical therapies before any surgery

Preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal acetate 10 mg · women with uterine fibroids

GnRHa treatment showed no clear difference in preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal… compared with other medical therapies before any surgery (moderate certainty).

1 finding from 1 review

5‐ASA vs placebo

Relapse, drop‐outs classed as relapse, grouped by length of · patients with maintenance of medically‐induced remission in Crohn's disease

5‐ASA showed no clear difference in relapse, drop‐outs classed as relapse, grouped by length of compared with placebo (moderate certainty).

3 findings from 1 review

Laparoscopic fundoplication vs medical management

Serious adverse events · Patients with gastro‐oesophageal reflux disease (GORD) in adults

It is very uncertain whether laparoscopic fundoplication changes serious adverse events compared with medical management (very low certainty).

1 finding from 1 review

Laparoscopic fundoplication vs medical management

(5 years or more) · Patients with gastro‐oesophageal reflux disease (GORD) in adults

It is very uncertain whether laparoscopic fundoplication changes (5 years or more) compared with medical management (very low certainty).

1 finding from 1 review

Transmyocardial laser revascularization vs medical treatment

Angina reduction ‐ NYHA scale Decrease in two angina classes or more · patients with refractory angina

Transmyocardial laser revascularization may leads to higher angina reduction Decrease in two angina classes or more compared with medical treatment (low certainty).

2 findings from 1 review