Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

429 questions · 431 findings · 83 reviews

No studies found 89 · 20.6%GRADE not reported 34 · 7.9%Very low 93 · 21.6%Low 110 · 25.5%Moderate 79 · 18.3%High 26 · 6%

Pre-operative radiotherapy (plus surgery) vs surgery

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative radiotherapy (plus surgery) showed no clear difference in total mortality compared with surgery alone; GRADE not reported.

1 finding from 1 review

Pre-operative and post-operative radiotherapy vs Post-operative radiotherapy alone

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative and post-operative radiotherapy showed no clear difference in total mortality compared with post-operative radiotherapy alone; GRADE not reported.

1 finding from 1 review

Pre-operative radiotherapy (plus surgery) vs surgery

Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative radiotherapy (plus surgery) showed no clear difference in locoregional control compared with surgery alone; GRADE not reported.

1 finding from 1 review

Fortification of salt with iron and iodine vs fortification of salt with iodine

Anaemia prevalence · participants were of any age or sex and from any country, regardless of baseline iron and iodine status

Fortification of salt with iron and iodine probably leads to lower prevalence of anaemia compared with fortification of salt with iodine (moderate certainty).

1 finding from 1 review

Fortification of salt with iron and iodine vs fortification of salt with iodine

Prevalence of iron deficiency anaemia · participants were of any age or sex and from any country, regardless of baseline iron and iodine status

Fortification of salt with iron and iodine may leads to lower prevalence of iron deficiency anaemia compared with fortification of salt with iodine (low certainty).

1 finding from 1 review

Combination of lidocaine intraperitoneal instillation plus intramuscular morphine vs lidocaine intraperitoneal instillation alone

Number of women requiring rescue medication · women undergoing PPTL under local anaesthesia

Combination of lidocaine intraperitoneal instillation plus… showed no clear difference in number of women requiring rescue medication compared with lidocaine intraperitoneal instillation alone (low certainty).

1 finding from 1 review

Scheduled surveillance vs clinical monitoring alone

Access thrombosis/vascular complication · people receiving haemodialysis to treat kidney failure and using a functioning AV access for haemodialysis.

Scheduled surveillance showed no clear difference in risk of access thrombosis compared with clinical monitoring alone (moderate certainty).

1 finding from 1 review