What do systematic reviews say?

Epidural local anaesthetic vs opioid‐based regimen

• Epidural local anaesthetics versus opioid‐based analgesic regimens for postoperative gastrointestinal paralysis,… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  22 studies · 1138 participants
  High

Epidural local anaesthetic vs opioid‐based regimen

• Epidural local anaesthetics versus opioid‐based analgesic regimens for postoperative gastrointestinal paralysis,… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  28 studies · 1559 participants
  Low

Epidural local anaesthetic vs opioid‐based regimen

• Epidural local anaesthetics versus opioid‐based analgesic regimens for postoperative gastrointestinal paralysis,… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  35 studies · 2731 participants
  Moderate

Epidural local anaesthetic vs opioid‐based regimen

Epidural local anaesthetic showed no clear difference in vomiting during first 24 hours compared with opioid‐based regimen (low certainty).

• Epidural local anaesthetics versus opioid‐based analgesic regimens for postoperative gastrointestinal paralysis,… 2016 · Cochrane Headline outcomes only
  RR 0.84 [0.57, 1.23]
  22 studies · 1154 participants
  Low

Epidural local anaesthetic vs opioid‐based regimen

Epidural local anaesthetic showed no clear difference in anastomotic leak compared with opioid‐based regimen (low certainty).

• Epidural local anaesthetics versus opioid‐based analgesic regimens for postoperative gastrointestinal paralysis,… 2016 · Cochrane Headline outcomes only
  RR 0.74 [0.41, 1.32]
  17 studies · 848 participants
  Low

Epidural local anaesthetic vs opioid‐based regimen

• Epidural local anaesthetics versus opioid‐based analgesic regimens for postoperative gastrointestinal paralysis,… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  30 studies · 2598 participants
  Very low

Anterior prolapse repair: native tissue vs biological graft

Anterior prolapse repair: native tissue showed no clear difference in awareness of prolapse (1‐2 years) compared with biological graft (low certainty).

• Surgery for women with anterior compartment prolapse 2016 · Cochrane Headline outcomes only
  RR 0.98 [0.52, 1.82]
  5 studies · 552 participants
  Low

Anterior prolapse repair: native tissue vs polypropylene mesh

Anterior prolapse repair: native tissue showed no clear difference in stress urinary incontinence (de novo) (1‐3 years) compared with polypropylene mesh (low certainty).

• Surgery for women with anterior compartment prolapse 2016 · Cochrane Headline outcomes only
  RR 0.67 [0.44, 1.01]
  6 studies · 957 participants
  Low

Anterior prolapse repair: native tissue vs polypropylene mesh

Anterior prolapse repair: native tissue showed no clear difference in dyspareunia (de novo) (1‐2 years) compared with polypropylene mesh (low certainty).

• Surgery for women with anterior compartment prolapse 2016 · Cochrane Headline outcomes only
  RR 0.54 [0.27, 1.06]
  8 studies · 583 participants
  Low

Anterior prolapse repair: native tissue vs absorbable mesh

It is very uncertain whether anterior prolapse repair: native tissue changes awareness of prolapse (2 years) compared with absorbable mesh (very low certainty).

• Surgery for women with anterior compartment prolapse 2016 · Cochrane Headline outcomes only
  RR 0.95 [0.7, 1.31]
  1 study · 54 participants
  Very low

Anterior prolapse repair: native tissue vs absorbable mesh

Anterior prolapse repair: native tissue probably leads to higher recurrent anterior compartment prolapse (3 months to 2 years) compared with absorbable mesh (moderate certainty).

• Surgery for women with anterior compartment prolapse 2016 · Cochrane Headline outcomes only
  RR 1.5 [1.09, 2.06]
  3 studies · 268 participants
  Moderate

Anterior prolapse repair: native tissue vs absorbable mesh

The review found no eligible studies for this question.

• Surgery for women with anterior compartment prolapse 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Anterior prolapse repair: native tissue vs absorbable mesh

It is very uncertain whether anterior prolapse repair: native tissue changes stress urinary incontinence (2 years) compared with absorbable mesh (very low certainty).

• Surgery for women with anterior compartment prolapse 2016 · Cochrane Headline outcomes only
  RR 0.72 [0.5, 1.05]
  1 study · 49 participants
  Very low

Anterior prolapse repair: native tissue vs biological graft

Anterior prolapse repair: native tissue probably leads to higher recurrent anterior compartment prolapse (1‐2 years) compared with biological graft (moderate certainty).

• Surgery for women with anterior compartment prolapse 2016 · Cochrane Headline outcomes only
  RR 1.32 [1.06, 1.65]
  8 studies · 701 participants
  Moderate

Anterior prolapse repair: native tissue vs biological graft

Anterior prolapse repair: native tissue showed no clear difference in stress urinary incontinence (1‐2 years) compared with biological graft (moderate certainty).

• Surgery for women with anterior compartment prolapse 2016 · Cochrane Headline outcomes only
  RR 1.44 [0.79, 2.64]
  2 studies · 218 participants
  Moderate

Anterior prolapse repair: native tissue vs biological graft

Anterior prolapse repair: native tissue showed no clear difference in dyspareunia (1‐2 years) compared with biological graft (low certainty).

• Surgery for women with anterior compartment prolapse 2016 · Cochrane Headline outcomes only
  RR 0.87 [0.39, 1.93]
  2 studies · 151 participants
  Low

Anterior prolapse repair: native tissue vs polypropylene mesh

Anterior prolapse repair: native tissue probably leads to higher awareness of prolapse (1‐3 years) compared with polypropylene mesh (moderate certainty).

• Surgery for women with anterior compartment prolapse 2016 · Cochrane Headline outcomes only
  RR 1.77 [1.37, 2.28]
  9 studies · 1133 participants
  Moderate

Anterior prolapse repair: native tissue vs polypropylene mesh

Anterior prolapse repair: native tissue may leads to higher recurrent anterior compartment prolapse (1‐3 years) compared with polypropylene mesh (low certainty).

• Surgery for women with anterior compartment prolapse 2016 · Cochrane Headline outcomes only
  RR 3.01 [2.52, 3.6]
  16 studies · 1976 participants
  Low

Propofol vs inhalation anaesthetics

• Deliberate hypotension with propofol under anaesthesia for functional endoscopic sinus surgery (FESS) 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 70 participants
  Very low

Propofol vs inhalation anaesthetics

• Deliberate hypotension with propofol under anaesthesia for functional endoscopic sinus surgery (FESS) 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 88 participants
  Moderate