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Evidence found and GRADE certainty

4,771 questions · 10,185 findings · 893 reviews

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No studies found 2,109 · 20.7%GRADE not reported 1,125 · 11%Very low 2,279 · 22.4%Low 2,514 · 24.7%Moderate 1,709 · 16.8%High 449 · 4.4%

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Aspirin vs vitamin K antagonist (VKA)

Major bleeding · ambulatory patients with multiple myeloma receiving immunomodulatory agents

It is very uncertain whether aspirin (ASA) changes major bleeding compared with vitamin K antagonist (VKA) (very low certainty).

2 findings from 1 review

Intervention not reported

All‐cause mortality · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

The intervention showed no clear difference in all‐cause mortality (low certainty).

1 finding from 1 review

Intervention not reported

Relapsec · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

The intervention probably leads to higher relapsec (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

It is very uncertain whether the intervention changes serious adverse events (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

The intervention showed no clear difference in adverse events (moderate certainty).

1 finding from 1 review

Er,Cr:YSGG laser (erbium,chromium:yttrium-scandium-gallium-garnet) vs Placebo (placebo laser or placebo agent) or no treatment

Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation

Er,Cr:YSGG laser (erbium,chromium:yttrium-scandium-gallium-garnet) showed no clear difference in changes in intensity of pain (VAS 0 to 10) tested through tactile… compared with placebo (placebo laser or placebo agent) or no treatment; GRADE not reported.

1 finding from 1 review

Zonisamide vs placebo

50% responder rate · people with focal epilepsy

Zonisamide probably leads to higher 50% responder rate (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

Zonisamide vs placebo

Withdrawal rates ‐ Any dose · people with focal epilepsy

Zonisamide probably leads to higher withdrawal rates (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

Zonisamide vs placebo

Frequency of adverse effects ‐ dizziness ( · people with focal epilepsy

Zonisamide probably leads to higher adverse effects: dizziness (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

Zonisamide vs placebo

Adverse effect: fatigue · people with focal epilepsy

Zonisamide probably leads to higher adverse effects: fatigue (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

Zonisamide vs placebo

Nausea · people with focal epilepsy

Zonisamide probably leads to higher adverse effects: nausea (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

Zonisamide vs placebo

Somnolence · people with focal epilepsy

Zonisamide probably leads to higher adverse effects: somnolence (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

EDTA vs placebo

Coronary heart disease mortality – CHD deaths · atherosclerotic cardiovascular disease

It is very uncertain whether EDTA changes coronary heart disease death compared with placebo (very low certainty).

1 finding from 1 review