Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,345 questions · 4,525 findings · 483 reviews

No studies found 1,024 · 22.6%GRADE not reported 388 · 8.6%Very low 1,172 · 25.9%Low 1,227 · 27.1%Moderate 576 · 12.7%High 138 · 3%

Peripheral nerve block vs systemic analgesia

Acute confusional state Complete loss of time and space orientation · adults undergoing elective primary total hip replacement

It is very uncertain whether peripheral nerve blocks changes acute confusional state Complete loss of time and space orientation compared with systemic analgesia (very low certainty).

1 finding from 1 review

Peripheral nerve block vs systemic analgesia

Length of hospital stay · adults undergoing elective primary total hip replacement

It is very uncertain whether peripheral nerve blocks changes hospital length of stay Objective actual measurement compared with systemic analgesia (very low certainty).

1 finding from 1 review

Peripheral nerve block vs systemic analgesia

Walking at postoperative day 1 Objective actual measurement · adults undergoing elective primary total hip replacement

It is very uncertain whether peripheral nerve blocks changes walking at postoperative day 1 Objective actual measurement compared with systemic analgesia (very low certainty).

1 finding from 1 review

Peripheral nerve block vs systemic analgesia

Patient satisfaction Subjective scales · adults undergoing elective primary total hip replacement

Peripheral nerve blocks may leads to higher patient satisfaction Subjective scales compared with systemic analgesia (low certainty).

1 finding from 1 review

Peripheral nerve block vs neuraxial block

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults undergoing elective primary total hip replacement

Peripheral nerve block showed no clear difference in pain at rest on arrival in postoperative care unit Verbal/visual… compared with neuraxial block (moderate certainty).

1 finding from 1 review

Intervention not reported

Survival · People with limited‐stage small‐cell lung cancer
1 finding from 1 review

Intervention not reported

Treatment related mortality · People with limited‐stage small‐cell lung cancer
1 finding from 1 review

Intervention not reported

Loco‐regional progression · People with limited‐stage small‐cell lung cancer
1 finding from 1 review

Intervention not reported

Quality of life · People with limited‐stage small‐cell lung cancer
1 finding from 1 review

Boost vs no boost

Disease-free survival (new disease, progression or mortality) · breast‐conserving radiotherapy for breast cancer

Boost showed no clear difference in disease‐free survival: disease progression/mortality at 5 years compared with no boost (low certainty).

1 finding from 1 review

Boost vs no boost

Cosmesis · breast‐conserving radiotherapy for breast cancer

Boost may leads to higher cosmesis, panel scored: fair or poor compared with no boost (low certainty).

2 findings from 1 review

Boost vs no boost

Subgroup analysis: local control ‐ > 40 years old, recurrence at 5 years · breast‐conserving radiotherapy for breast cancer

Boost leads to lower subgroup analysis: local control ‐ > 40 years old, recurrence at 5… compared with no boost (high certainty).

1 finding from 1 review