Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,695 questions · 4,979 findings · 433 reviews

No studies found 998 · 20%GRADE not reported 1,140 · 22.9%Very low 1,024 · 20.6%Low 1,029 · 20.7%Moderate 636 · 12.8%High 152 · 3.1%

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Normalcy of diet (supplemental nutrition: TPN, PEG, nasogastric tube or IV hydration) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in normalcy of diet (supplemental nutrition: TPN, PEG, nasogastric tube… compared with placebo; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Interruptions to cancer treatment (chemotherapy delays/discontinuations) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in interruptions to cancer treatment (chemotherapy… compared with placebo; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Interruptions to cancer treatment (unscheduled radiotherapy breaks of 5 or more days) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in interruptions to cancer treatment (unscheduled radiotherapy breaks… compared with placebo; GRADE not reported.

1 finding from 1 review

Intervention not reported

Change in weight (kg):1 at 12 months · adults and children with cystic fibrosis
1 finding from 1 review

Intervention not reported

Change in height (cm):1 at 12 months · adults and children with cystic fibrosis
1 finding from 1 review

Intervention not reported

Change in total calories (Kcal/day): at 12 months · adults and children with cystic fibrosis
1 finding from 1 review

Intervention not reported

Change in total protein (g/day): at 12 months · adults and children with cystic fibrosis
1 finding from 1 review

Intervention not reported

Change in total fat (g/day): at 12 months · adults and children with cystic fibrosis
1 finding from 1 review

Intervention not reported

Adverse events: · adults and children with cystic fibrosis
1 finding from 1 review

Intervention not reported

Change in lung function ‐ FEV₁ (% predicted): at 12 months · adults and children with cystic fibrosis
1 finding from 1 review

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

Live birth or ongoing pregnancy · ovarian stimulation protocols for women undergoing ART

Progestogen showed no clear difference in live birth or ongoing pregnancy (Prog + Ant vs Ant) compared with placebo or no pretreatment (low certainty).

2 findings from 1 review

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

Pregnancy loss · ovarian stimulation protocols for women undergoing ART

Progestogen showed no clear difference in pregnancy loss (Prog + Ag vs Ag) compared with placebo or no pretreatment (low certainty).

2 findings from 1 review

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

Multiple pregnancy rate · ovarian stimulation protocols for women undergoing ART

The review found no eligible studies for this question.

2 findings from 1 review

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

OHSS · ovarian stimulation protocols for women undergoing ART

The review found no eligible studies for this question.

2 findings from 1 review

Oestrogen vs no pretreatment

Live birth or ongoing pregnancy · ovarian stimulation protocols for women undergoing ART

Oestrogen showed no clear difference in live birth or ongoing pregnancy (Oestr + Ant vs Ant) compared with no pretreatment (moderate certainty).

2 findings from 1 review

Oestrogen vs no pretreatment

Pregnancy loss · ovarian stimulation protocols for women undergoing ART

It is very uncertain whether oestrogen changes pregnancy loss (Oestr + Ant vs Ant) compared with no pretreatment (very low certainty).

2 findings from 1 review

Oestrogen vs no pretreatment

Multiple pregnancy rate · ovarian stimulation protocols for women undergoing ART

The review found no eligible studies for this question.

2 findings from 1 review