Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,749 questions · 17,858 findings · 1,266 reviews

No studies found 4,359 · 24.4%GRADE not reported 2,348 · 13.1%Very low 4,634 · 25.9%Low 4,000 · 22.4%Moderate 2,052 · 11.5%High 465 · 2.6%

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Artemisia desertorum spreng (Yunnan) vs placebo

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Artemisia desertorum spreng (Yunnan) showed no clear difference in presence of dry socket compared with placebo; GRADE not reported.

1 finding from 1 review

Chlorhexidine 0.2% socket irrigation (monoject syringe) vs Chlorhexidine 0.2% mouthrinse

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine 0.2% socket irrigation (monoject syringe) led to lower presence of dry socket compared with chlorhexidine 0.2% mouthrinse; GRADE not reported.

1 finding from 1 review

Autofluorescence-guided bone surgery vs Tetracycline fluorescence-guided bone surgery

Healing of MRONJ (mucosal integrity) · People with MRONJ referred for surgical treatment

It is very uncertain whether autofluorescence-guided bone surgery changes healing of MRONJ (mucosal integrity) compared with tetracycline fluorescence-guided bone surgery (very low certainty).

1 finding from 1 review

Topical anaesthetic gel (prilocaine-lidocaine) vs Eugenol

Pain at 48 hours (VAS 0-10) · Adults (>18 years) with established dry socket following permanent tooth extraction

Topical anaesthetic gel (prilocaine-lidocaine) showed no clear difference in pain at 48 hours (VAS 0-10) compared with eugenol; GRADE not reported.

1 finding from 1 review

Chlorhexidine gel (0.2%, intrasocket) vs Chlorhexidine mouthrinse

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine gel (0.2%, intrasocket) showed no clear difference in presence of dry socket compared with chlorhexidine rinse (0.12%) (low certainty).

1 finding from 1 review

Teriparatide 56.5 microg weekly in addition to standard care vs Teriparatide 20 microg daily in addition to standard care

Healing of MRONJ (remission) · People with established (manifest) MRONJ

It is very uncertain whether teriparatide 56.5 microg weekly in addition to standard care changes healing of MRONJ (remission) compared with teriparatide 20 microg daily in addition to standard care (very low certainty).

1 finding from 1 review

Tap water irrigation (monoject syringe) vs No rinsing

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Tap water irrigation (monoject syringe) led to lower presence of dry socket compared with no rinsing; GRADE not reported.

1 finding from 1 review

Chlorhexidine gel vs Chlorhexidine, 0.2% to 2% (solution or gel)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine gel 1% showed no clear difference in presence of dry socket compared with chlorhexidine gel 0.2%; GRADE not reported.

1 finding from 1 review

Subperiosteal prepared (SPP) wound closure after tooth extraction vs Epiperiosteal prepared (EPP) wound closure after tooth extraction

MRONJ after tooth extraction (incidence proportion) · People on antiresorptive treatment undergoing tooth extraction (at risk of MRONJ)

Subperiosteal prepared (SPP) wound closure after tooth extraction showed no clear difference in MRONJ after tooth extraction (incidence proportion) compared with epiperiosteal prepared (EPP) wound closure after tooth extraction (low certainty).

1 finding from 1 review

Honey (Manuka, topical) vs Chlorhexidine rinse (0.2%)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Honey (Manuka, topical) showed no clear difference in presence of dry socket compared with chlorhexidine rinse (0.2%); GRADE not reported.

1 finding from 1 review

Chlorhexidine gel (0.2%, intrasocket) vs placebo or no treatment

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine gel (0.2%, intrasocket) probably leads to lower presence of dry socket compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Artemisia desertorum spreng (Shahaosan) vs Artemisia desertorum spreng (Yunnan)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Artemisia desertorum spreng (Shahaosan) showed no clear difference in presence of dry socket compared with artemisia desertorum spreng (Yunnan); GRADE not reported.

1 finding from 1 review

Dental extraction protocol with plasma rich in growth factors (PRGF) inserted into the postextraction alveolus vs Standard dental extraction protocol without PRGF

MRONJ (incidence proportion) · People with cancer treated with intravenous bisphosphonates undergoing dental extractions (at risk of MRONJ)

It is very uncertain whether dental extraction protocol with plasma rich in growth factors (PRGF)… changes MRONJ (incidence proportion) compared with standard dental extraction protocol without PRGF (very low certainty).

1 finding from 1 review

Dental examinations at three-month intervals and preventive treatments vs usual care

MRONJ (incidence rate: cases per patient-year) · Men with metastatic prostate cancer receiving intravenous zoledronic acid (at risk of MRONJ)

It is very uncertain whether dental examinations at three-month intervals and preventive treatments changes MRONJ (incidence rate: cases per patient-year) compared with standard care (very low certainty).

1 finding from 1 review