Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,667 questions · 21,760 findings · 2,177 reviews

No studies found 4,173 · 19.2%GRADE not reported 2,300 · 10.6%Very low 5,276 · 24.2%Low 5,764 · 26.5%Moderate 3,298 · 15.2%High 949 · 4.4%

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Heparin vs normal saline solution locking

CVC‐related bloodstream infections (positive microbiological culture, participant as unit of analysis) · adults with CVCs

It is very uncertain whether heparin changes CVC‐related bloodstream infections (positive microbiological… compared with normal saline solution locking (very low certainty).

1 finding from 1 review

Vitamin A vs placebo or usual care

Diarrhoea incidence Mean episodes per child per year · children aged between 6 months and 5 years

Vitamin A supplementation may leads to lower diarrhoea incidence Mean episodes per child per year compared with placebo or usual care (low certainty).

1 finding from 1 review

Vitamin A vs placebo or usual care

Measles incidence Mean episodes of measles per child per year · children aged between 6 months and 5 years

Vitamin A supplementation probably leads to lower measles incidence Mean episodes of measles per child per year compared with placebo or usual care (moderate certainty).

1 finding from 1 review

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Post‐ERCP pancreatitis · Patients undergoing diagnostic or therapeutic ERCP

Guidewire‐assisted cannulation probably leads to lower post‐ERCP pancreatitis (PEP) compared with contrast‐assisted cannulation (moderate certainty).

1 finding from 1 review

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Primary cannulation success · Patients undergoing diagnostic or therapeutic ERCP

Guidewire‐assisted cannulation may leads to higher primary cannulation success compared with contrast‐assisted cannulation (low certainty).

1 finding from 1 review

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Overall success of cannulation · Patients undergoing diagnostic or therapeutic ERCP

Guidewire‐assisted cannulation showed no clear difference in overall cannulation success compared with contrast‐assisted cannulation (moderate certainty).

1 finding from 1 review

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Post‐sphincterotomy bleeding · Patients undergoing diagnostic or therapeutic ERCP

Guidewire‐assisted cannulation showed no clear difference in post‐sphincterotomy bleeding compared with contrast‐assisted cannulation (low certainty).

1 finding from 1 review