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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

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No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Benzoyl peroxide vs placebo or no treatment

Participant's global self‐assessment of improvement (long‐term data) · participants with acne

Benzoyl peroxide may leads to higher participant's global self‐assessment of improvement (long‐term data) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Benzoyl peroxide vs erythromycin

Participant's global self‐assessment of improvement (long‐term data) ‐ not measured · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Benzoyl peroxide vs erythromycin

Withdrawals due to adverse outcomes · participants with acne

It is very uncertain whether benzoyl peroxide changes withdrawal due to adverse effects (medium‐term data) Treatment… compared with erythromycin (very low certainty).

1 finding from 1 review

Benzoyl peroxide vs salicylic acid

Participant's global self‐assessment of improvement (long‐term data) ‐ not measured · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Benzoyl peroxide vs salicylic acid

Adverse effect/event: 2. Adverse effects ‐ any ‐ medium‐termonly · participants with acne

It is very uncertain whether benzoyl peroxide changes total number of participants with any adverse events (medium‐term… compared with salicylic acid (very low certainty).

1 finding from 1 review

Benzoyl peroxide vs placebo or no treatment

Adverse effects (side effects; treatment withdrawals) · participants with acne

Benzoyl peroxide may leads to higher withdrawal due to adverse effects (long‐term data) Treatment… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Benzoyl peroxide vs placebo or no treatment

Total number of participants with any adverse events (long‐term data) Treatment duration: range 10 weeks to 12 weeks · participants with acne

It is very uncertain whether benzoyl peroxide changes total number of participants with any adverse events (long‐term… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Benzoyl peroxide vs adapalene

Participant's global self‐assessment of improvement (long‐term data) · participants with acne

Benzoyl peroxide showed no clear difference in participant's global self‐assessment of improvement (long‐term data) compared with adapalene (low certainty).

1 finding from 1 review

Benzoyl peroxide vs adapalene

Withdrawals due to adverse outcomes · participants with acne

It is very uncertain whether benzoyl peroxide changes withdrawal due to adverse effects (long‐term data) Treatment… compared with adapalene (very low certainty).

1 finding from 1 review

Benzoyl peroxide vs adapalene

Adverse event data · participants with acne

It is very uncertain whether benzoyl peroxide changes total number of participants with any adverse events (long‐term… compared with adapalene (very low certainty).

1 finding from 1 review

Benzoyl peroxide vs clindamycin

Participant's global self‐assessment of improvement (long‐term data) · participants with acne

Benzoyl peroxide showed no clear difference in participant's global self‐assessment of improvement (long‐term data) compared with clindamycin (low certainty).

1 finding from 1 review

Benzoyl peroxide vs clindamycin

Adverse effects (side effects; treatment withdrawals) · participants with acne

It is very uncertain whether benzoyl peroxide changes withdrawal due to adverse effects (long‐term data) Treatment… compared with clindamycin (very low certainty).

1 finding from 1 review

Benzoyl peroxide vs clindamycin

Total number of participants with any adverse events (long‐term data) Treatment duration: range 10 weeks to 12 weeks · participants with acne

Benzoyl peroxide showed no clear difference in total number of participants with any adverse events (long‐term… compared with clindamycin (moderate certainty).

1 finding from 1 review

Azelaic acid vs adapalene

Participants' global self‐assessment of acne improvement · participants with acne

It is very uncertain whether azelaic acid changes participants' global self‐assessment of acne improvement Improved to… compared with adapalene (very low certainty).

1 finding from 1 review