Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

459 questions · 589 findings · 78 reviews · Oral Health

No studies found 64 · 10.9%GRADE not reported 366 · 62.1%Very low 90 · 15.3%Low 49 · 8.3%Moderate 10 · 1.7%High 10 · 1.7%

Hand mallet (osteotomes) vs Electric mallet

Complication at augmented site · Patients undergoing one-stage crestal maxillary sinus lift without bone grafts (baseline residual bone height about 6.5 mm)

Hand mallet (osteotomes) showed no clear difference in complications at augmented site compared with electric mallet; GRADE not reported.

1 finding from 1 review

Hand mallet (osteotomes) vs Electric mallet

Bone gain · Patients undergoing one-stage crestal maxillary sinus lift without bone grafts (baseline residual bone height about 6.5 mm)

Hand mallet (osteotomes) showed no clear difference in bone gain compared with electric mallet; GRADE not reported.

1 finding from 1 review

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

Damage to the teeth (e.g. tooth decay) · Children and adults with fixed orthodontic brackets bonded to incisors, canines and premolars

The review found no eligible studies for this question.

1 finding from 1 review

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

Bond failure rate · Children and adults with fixed orthodontic brackets bonded to incisors, canines and premolars

Self etching primers (one-step etchant and primer system) showed no clear difference in bond failure rate compared with conventional etchants (two-step etch and prime method using 37%… (low certainty).

1 finding from 1 review

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

Participant satisfaction · Children and adults with fixed orthodontic brackets bonded to incisors, canines and premolars

The review found no eligible studies for this question.

1 finding from 1 review

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

Decay (decalcification) associated with or around the etching field · Children and adults with fixed orthodontic brackets bonded to incisors, canines and premolars
1 finding from 1 review
  • Decay (decalcification) associated with or around the etching field: Only one study (Ghiz 2009) assessed this outcome but data were reported at the tooth level rather than at the participant level and therefore was not…
    1 study · 25 participants
    GRADE not reported

Absorbed drug (fluconazole or ketoconazole) vs Antifungal drugs not absorbed from GI tract

Mycological: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Absorbed drug (fluconazole or ketoconazole) led to higher mycological: eradication of oral candidiasis compared with drug not absorbed from GI tract (amphotericin B or nystatin); GRADE not reported.

1 finding from 1 review

Absorbed drug (fluconazole or ketoconazole) vs Antifungal drugs not absorbed from GI tract

Clinical: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Absorbed drug (fluconazole or ketoconazole) led to higher clinical: eradication of oral candidiasis compared with drug not absorbed from GI tract (amphotericin B or nystatin); GRADE not reported.

1 finding from 1 review

Partially absorbed antifungal drug (e.g., clotrimazole, miconazole) vs Drug not absorbed from GI tract (e.g., nystatin, amphotericin B)

Outcome not reported · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

The review found no eligible studies for this question.

1 finding from 1 review

Morphine vs Tricyclic antidepressant (nortriptyline)

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Morphine led to lower average pain scores (0-100 VAS) compared with tricyclic antidepressant (nortriptyline); GRADE not reported.

1 finding from 1 review

Orthodontic treatment with appliances inducing stable, permanent orthodontic tooth movement (splints worn 8 to 12 weeks and surgical interventions excluded) vs Control: no treatment, placebo, or reassurance

Development of TMD (onset/incidence of signs and symptoms) · People without TMD at baseline undergoing orthodontic treatment (TMD clinically absent at baseline); no age restriction provided follow-up…

The review found no eligible studies for this question.

1 finding from 1 review

Brushing vs Effervescent tablets

Visual plaque score · American complete denture (CD) wearers
1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    12 weeks
    Tarbet 1984 compared brushing with two types of effervescent tablets. No standard deviations were reported and therefore no data were entered for this outcome. Brushing was associated with significantly lower plaque…
    1 study · 75 participants
    GRADE not reported

Occlusal splint vs Transcutaneous electric nerve stimulation (TENS)

Pain in temporomandibular joint (TMJ) · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…
1 finding from 1 review

Occlusal splint vs Transcutaneous electric nerve stimulation (TENS)

Clicks in TMJ on oral opening and closing · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…

Occlusal splint showed no clear difference in clicks in TMJ on oral opening and closing compared with transcutaneous electric nerve stimulation (TENS); GRADE not reported.

2 findings from 1 review

Occlusal splint vs Transcutaneous electric nerve stimulation (TENS)

Headache · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…
1 finding from 1 review
  • Occlusal splint versus TENS, headaches (Alvarez-Arenal 2002): the event did not occur in either group, so the risk ratio was not estimable (Risk Ratio, M-H, Fixed, 95% CI; subtotals only).
    1 study
    GRADE not reported

Ion-releasing restorations (IRR): RMGIC, HVGIC, GIC, compomer/PMRC, giomer vs Composite resin (CR), including bulk-fill composite

Occlusion · Children receiving dental restorations (aged 4-11 years; primary teeth; Class I/II/V cavities)

Occlusion was assessed in a single trial and was not pooled or GRADE-rated (ungraded).

1 finding from 1 review

Ion-releasing restorations (IRR): RMGIC, HVGIC, GIC, compomer/PMRC, giomer vs Composite resin (CR), including bulk-fill composite

Adequate marginal adaptation · Children receiving dental restorations (aged 4-11 years; primary teeth; Class I/II/V cavities)

No significant difference between IRR and CR in marginal adaptation (high certainty).

1 finding from 1 review

Ion-releasing restorations (IRR): RMGIC, HVGIC, GIC, compomer/PMRC, giomer vs Composite resin (CR), including bulk-fill composite

Absence of marginal discoloration · Children receiving dental restorations (aged 4-11 years; primary teeth; Class I/II/V cavities)

No significant difference between IRR and CR in marginal discoloration (moderate certainty; downgraded for inconsistency).

1 finding from 1 review