What do systematic reviews say?

Vilanterol and fluticasone furoate vs placebo

• Vilanterol and fluticasone furoate for asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 2013 participants
  Very low

Vilanterol and fluticasone furoate vs placebo

• Vilanterol and fluticasone furoate for asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2013 participants
  Very low

Vilanterol and fluticasone furoate vs placebo

Vilanterol and fluticasone furoate showed no clear difference in FEV1 compared with placebo (moderate certainty).

• Vilanterol and fluticasone furoate for asthma 2016 · Cochrane Headline outcomes only
  MD 0.17
  1 study · 100 participants
  Moderate

Vilanterol and fluticasone furoate vs placebo

Vilanterol and fluticasone furoate showed no clear difference in peak expiratory flow compared with placebo (moderate certainty).

• Vilanterol and fluticasone furoate for asthma 2016 · Cochrane Headline outcomes only
  MD 33.3
  2012 participants
  Moderate

Vilanterol and fluticasone furoate vs placebo

Vilanterol and fluticasone furoate showed no clear difference in asthma symptoms compared with placebo (moderate certainty).

• Vilanterol and fluticasone furoate for asthma 2016 · Cochrane Headline outcomes only
  MD 17.9
  1 study · 2012 participants
  Moderate

Vilanterol and fluticasone furoate vs placebo

• Vilanterol and fluticasone furoate for asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  8 participants
  Moderate

MgSO4 vs placebo

MgSO4 may leads to lower hospital admissions compared with placebo (low certainty).

• Intravenous magnesium sulfate for treating children with acute asthma in the emergency department 2016 · Cochrane Headline outcomes only
  OR 0.32 [0.14, 0.74]
  3 studies · 115 participants
  Low

MgSO4 vs placebo

• Intravenous magnesium sulfate for treating children with acute asthma in the emergency department 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 27 participants
  Low

MgSO4 vs placebo

MgSO4 showed no clear difference in return to ED within 48 hours compared with placebo (low certainty).

• Intravenous magnesium sulfate for treating children with acute asthma in the emergency department 2016 · Cochrane Headline outcomes only
  OR 0.4 [0.02, 10.3]
  2 studies · 85 participants
  Low

MgSO4 vs placebo

• Intravenous magnesium sulfate for treating children with acute asthma in the emergency department 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 47 participants
  Low

Maintenance LTRA vs placebo

Maintenance LTRA showed no clear difference in number of participants experiencing one or more episode requiring… compared with placebo (moderate certainty).

• Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
  OR 1.2 [0.7, 2.06]
  1 study · 347 participants
  Moderate

Intermittent LTRA vs placebo

The review found no eligible studies for this question.

• Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Maintenance LTRA vs placebo

Maintenance LTRA showed no clear difference in number of participants experiencing one or more episodes requiring… compared with placebo (moderate certainty).

• Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
  OR 0.66 [0.37, 1.2]
  1 study · 347 participants
  Moderate

Maintenance LTRA vs placebo

Maintenance LTRA showed no clear difference in number of participants experiencing one or more episodes requiring… compared with placebo (moderate certainty).

• Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
  OR 0.65 [0.23, 1.87]
  1 study · 347 participants
  Moderate

Maintenance LTRA vs placebo

Maintenance LTRA showed no clear difference in withdrawals ‐ Total number of withdrawals compared with placebo (moderate certainty).

• Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
  OR 0.87 [0.66, 1.13]
  2 studies · 1729 participants
  Moderate

Maintenance LTRA vs placebo

The review found no eligible studies for this question.

• Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intermittent LTRA vs placebo

Intermittent LTRA showed no clear difference in number of participants experiencing one or more episode requiring… compared with placebo (moderate certainty).

• Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
  RR 0.85 [0.64, 1.14]
  2 studies · 343 participants
  Moderate

Intermittent LTRA vs placebo

Intermittent LTRA showed no clear difference in number of participants experiencing one or more episodes requiring… compared with placebo (moderate certainty).

• Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
  OR 1 [0.49, 2.02]
  1 study · 141 participants
  Moderate

Intermittent LTRA vs placebo

Intermittent LTRA showed no clear difference in number of participants experiencing one or more episodes requiring… compared with placebo (moderate certainty).

• Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
  OR 0.73 [0.2, 2.73]
  1 study · 141 participants
  Moderate

Intermittent LTRA vs placebo

Intermittent LTRA showed no clear difference in withdrawals ‐ Total number of withdrawals compared with placebo (moderate certainty).

• Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
  OR 1.03 [0.79, 1.35]
  2 studies · 1402 participants
  Moderate