Findings

What do systematic reviews say?

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

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No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Necrotising enterocolitis · preterm infants

Lower showed no clear difference in necrotising enterocolitis compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).

1 finding from 1 review

Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm… 2018 · Cochrane Headline outcomes only
RR 0.98 [0.51, 1.87]
8 studies · 807 participants
Low

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Chronic lung disease · preterm infants

It is very uncertain whether lower changes chronic lung disease (36 weeks' corrected age) compared with higher oxygen concentrations titrated to target oxygen saturations… (very low certainty).

1 finding from 1 review

Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm… 2018 · Cochrane Headline outcomes only
RR 0.91 [0.72, 1.14]
9 studies · 862 participants
Very low

Anticipated low‐responders: higher vs lower dose of FSH

300/450 IU vs 150 IU · women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure

Anticipated low responders: higher showed no clear difference in 300/450 IU vs 150 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… 2024 · Cochrane Headline outcomes only
OR 1.2 [0.78, 1.86]
3 studies · 538 participants
Low

Anticipated low‐responders: higher vs lower dose of FSH

400/450 IU vs 300 IU · women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure

Anticipated low responders: higher showed no clear difference in 400/450 IU vs 300 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… 2024 · Cochrane Headline outcomes only
OR 0.77 [0.19, 3.19]
1 study · 62 participants
Low

Anticipated low‐responders: higher vs lower dose of FSH

IU vs 450 IU · women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure

Anticipated low responders: higher showed no clear difference in IU vs 450 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… 2024 · Cochrane Headline outcomes only
OR 1.33 [0.71, 2.52]
1 study · 356 participants
Low

Treatment of eclampsia: lower‐dose regimens vs standard‐dose strategies

Death of the baby before discharge: perinatal death · women with eclampsia

It is very uncertain whether treatment of eclampsia: lower‐dose regimens changes death of the baby before discharge: perinatal death: lower dose… compared with standard‐dose regimens (very low certainty).

1 finding from 1 review

Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
RR 1.52 [0.57, 4.1]
1 study · 72 participants
Very low

Treatment of eclampsia: lower‐dose regimens vs standard‐dose strategies

Recurrence of convulsions · women with eclampsia

It is very uncertain whether treatment of eclampsia: lower‐dose regimens changes recurrence of convulsions: lower dose versus Pritchard regimen compared with standard‐dose regimens (very low certainty).

1 finding from 1 review

Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
RR 1.69 [0.16, 17.84]
1 study · 72 participants
Very low

Treatment of eclampsia: lower‐dose regimens vs standard‐dose strategies

Severe morbidity (renal failure): lower dose versus Pritchard regimen · women with eclampsia

It is very uncertain whether treatment of eclampsia: lower‐dose regimens changes severe morbidity (renal failure): lower dose versus Pritchard regimen compared with standard‐dose regimens (very low certainty).

1 finding from 1 review

Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
RR 0.85 [0.06, 13.01]
1 study · 72 participants
Very low

Very low protein diet vs low or normal protein diet

Death (all causes) · non‐diabetic adults with CKD

Very low protein diet showed no clear difference in death (all causes) compared with low or normal protein diet (moderate certainty).

1 finding from 1 review

Low protein diets for non‐diabetic adults with chronic kidney disease 2020 · Cochrane Headline outcomes only
RR 1.26 [0.62, 2.54]
6 studies · 681 participants
Moderate

Very low protein diet vs low or normal protein diet

ESKD · non‐diabetic adults with CKD

Very low protein diet probably leads to lower ESKD compared with low or normal protein diet (moderate certainty).

1 finding from 1 review

Low protein diets for non‐diabetic adults with chronic kidney disease 2020 · Cochrane Headline outcomes only
RR 0.64 [0.49, 0.85]
10 studies · 1010 participants
Moderate

Very low protein diet vs low or normal protein diet

End or change in GFR · non‐diabetic adults with CKD

1 finding from 1 review

Low protein diets for non‐diabetic adults with chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 456 participants
Low