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What do systematic reviews say?

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Evidence found and GRADE certainty

720 questions · 751 findings · 105 reviews

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No studies found 193 · 25.7%GRADE not reported 37 · 4.9%Very low 212 · 28.2%Low 193 · 25.7%Moderate 99 · 13.2%High 17 · 2.3%

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Hospital readmission · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in readmission to hospital following discharge compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Acute kidney injury · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in acute kidney injury (adverse event) (from admission to discharge) compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Cumulative live birth · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) showed no clear difference in cumulative live birth compared with multiple embryo transfer (low certainty).

1 finding from 1 review

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Multiple pregnancy · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) probably leads to lower multiple pregnancy compared with multiple embryo transfer (moderate certainty).

1 finding from 1 review

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Clinical pregnancy rate · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) showed no clear difference in clinical pregnancy rate compared with multiple embryo transfer (low certainty).

1 finding from 1 review

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Miscarriage · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) showed no clear difference in miscarriage rate compared with multiple embryo transfer (low certainty).

1 finding from 1 review

Double vs single‐injection technique

Primary anaesthesia failure (incomplete sensory block) · Adult patients undergoing hand, wrist or forearm surgery

Double leads to lower primary anaesthesia failure (incomplete sensory block) compared with single‐injection technique (high certainty).

1 finding from 1 review