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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

67 questions in 8 reviews · Methodology

current versions
No studies 15 · 22.4%Ungraded 0 · 0%Very low 22 · 32.8%Low 19 · 28.4%Moderate 8 · 11.9%High 3 · 4.5%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Central monitoring with triggered vs untriggered on‐site visits
Impact of the monitoring strategy on participant recruitment · clinical trials in all fields of health care
Monitoring strategies for clinical intervention studies (2021) · Cochrane
no estimate extractedNRNo studies
Central monitoring with triggered vs untriggered on‐site visits
Impact of the monitoring strategy on · clinical trials in all fields of health care
Monitoring strategies for clinical intervention studies (2021) · Cochrane
no estimate extractedNRNo studies
Central monitoring with triggered vs untriggered on‐site visits
Effect of the monitoring strategy on resource use · clinical trials in all fields of health care
Monitoring strategies for clinical intervention studies (2021) · Cochrane
no estimate extractedNRNo studies
Central and local monitoring only vs central and local monitoring with on‐site visits
Combined outcome of proportion of participants with major or critical monitoring findings · clinical trials in all fields of health care
Monitoring strategies for clinical intervention studies (2021) · Cochrane
OR 1.7 [1.1, 2.7]1 study · 4371 participantsModerate
Intervention NR
Estimated treatment effect measured as Z‐scores*** after adjustment for the number of patients
Financial conflicts of interest in systematic reviews: associations with results, conclusions, and… (2019) · Cochrane
no estimate extractedNRVery low
Intervention NR
Frequency of statistically favourable results
Financial conflicts of interest in systematic reviews: associations with results, conclusions, and… (2019) · Cochrane
RR 0.84 [0.62, 1.14]NRVery low
Intervention NR
Frequency of favourable conclusions
Financial conflicts of interest in systematic reviews: associations with results, conclusions, and… (2019) · Cochrane
RR 1.98 [1.26, 3.11]NRLow
Open trial vs blinded trial
Number recruited · individuals eligible for a trial
Strategies to improve recruitment to randomised trials (2018) · Cochrane
RR 1.25 [1.18, 1.34]2 studies · 4833 participantsHigh
Telephone reminder vs no telephone reminder
Number recruited · individuals eligible for a trial
Strategies to improve recruitment to randomised trials (2018) · Cochrane
RR 1.9 [1.35, 2.67]2 studies · 978 participantsHigh
Bespoke, user‐tested participant information leaflet (PIL) vs usual PIL
Willingness to participate/number recruited · individuals eligible for trial
Strategies to improve recruitment to randomised trials (2018) · Cochrane
RR 1.15 [0.92, 1.44]3 studies · 6634 participantsHigh
Brief participant information leaflet (PIL) vs usual PIL
Number recruited · individuals eligible for a trial
Strategies to improve recruitment to randomised trials (2018) · Cochrane
RR 1 [0.93, 1.07]2 studies · 4633 participantsModerate
Participant information leaflet (PIL) developed with feedback from users vs usual PIL
Number recruited · individuals eligible for a trial
Strategies to improve recruitment to randomised trials (2018) · Cochrane
RR 1.09 [0.96, 1.25]2 studies · 16763 participantsModerate
Providing information by video vs by standard means alone
Number recruited · individuals eligible for trial
Strategies to improve recruitment to randomised trials (2018) · Cochrane
RR 1.08 [0.89, 1.31]3 studies · 4695 participantsVery low
Financial incentive vs no incentive
Number recruited · individuals eligible for a trial
Strategies to improve recruitment to randomised trials (2018) · Cochrane
RR 1.48 [0.85, 2.58]6 studies · 1506 participantsModerate
Industry sponsored vs non‐industry sponsored studies
Number of studies with favorable efficacy results · industry sponsorship and study results
Industry sponsorship and research outcome (2017) · Cochrane
no estimate extracted25 studies · 2923 participantsModerate
Industry sponsored vs non‐industry sponsored studies
Number of studies with favorable harms results · industry sponsorship and study results
Industry sponsorship and research outcome (2017) · Cochrane
no estimate extracted4 studies · 826 participantsVery low
Industry sponsored vs non‐industry sponsored studies
Number of studies with favorable conclusions · industry sponsorship and study results
Industry sponsorship and research outcome (2017) · Cochrane
no estimate extracted29 studies · 4583 participantsLow