Vitamin D vs placebo
Respiratory infections · people with sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Findings
What do systematic reviews say?
63 questions · 65 findings · 7 reviews · Cystic Fibrosis and Genetic Disorders
No studies found 40 · 61.5%GRADE not reported 1 · 1.5%Very low 9 · 13.8%Low 11 · 16.9%Moderate 4 · 6.2%High 0 · 0%
Vitamin D vs placebo
HRQoL score (physical functioning) (change from baseline) · people with sickle cell disease
1 finding from 1 review
- no estimate extracted1 study · 37 participantsLow
Vitamin D 100,000 IU/month vs 12,000 IU/month
Adverse events · people with sickle cell disease
1 finding from 1 review
- no estimate extracted1 study · 62 participantsLow
Vitamin D 100,000 IU/month vs 12,000 IU/month
Pain: presence of pain (slight or moderate) at 1 year · people with sickle cell disease
Vitamin D 100,000 IU/month showed no clear difference in presence of pain compared with 12,000 IU/month (moderate certainty).
1 finding from 1 review
- RR 1 [0.62, 1.62]1 study · 62 participantsModerate
Vitamin D 100,000 IU/month vs 12,000 IU/month
Acute chest syndrome ( · people with sickle cell disease
1 finding from 1 review
- no estimate extracted1 study · 62 participantsModerate
Vitamin D 100,000 IU/month vs 12,000 IU/month
Respiratory infections · people with sickle cell disease
1 finding from 1 review
- no estimate extracted1 study · 62 participantsModerate
Vitamin D 100,000 IU/month vs 12,000 IU/month
HRQoL (using a validated scale) · people with sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Vitamin D 100,000 IU/month vs 12,000 IU/month
Total body BMD measured by DEXA (% change from baseline) · people with sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings: fat‐soluble vitamin E vs control
Body‐mass index (BMI) · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings: fat‐soluble vitamin E vs control
Height (cm) · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings: fat‐soluble vitamin E vs control
FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings: water‐soluble vitamin E vs control
Body‐mass index (BMI) · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings: water‐soluble vitamin E vs control
Height (cm) · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings: water‐soluble vitamin E vs control
FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Intervention not reported
Vitamin A deficiency disorders · children and adults with CF
The review found no eligible studies for this question.
1 finding from 1 review
- Vitamin A and beta (β)‐carotene supplementation for cystic fibrosis 2018 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
Frequency of pain crises in the · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes frequency of pain crisis compared with placebo (very low certainty).
1 finding from 1 review
- RR 1.18 [0.64, 2.18]1 study · 83 participantsVery low
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
Severity of pain (use of opioid analgesics) · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes severity of pain (use of opioid analgesics) compared with placebo (very low certainty).
1 finding from 1 review
- RR 1.33 [0.4, 4.37]1 study · 83 participantsVery low
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
QoL of participants living with SCD and their caregivers · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
Adverse effects · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes adverse effects compared with placebo (very low certainty).
1 finding from 1 review
- RR 0.56 [0.31, 1]1 study · 83 participantsVery low
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
Frequency of hospitalization · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found