Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

57 questions · 60 findings · 5 reviews · Skin

No studies found 23 · 38.3%GRADE not reported 4 · 6.7%Very low 10 · 16.7%Low 2 · 3.3%Moderate 17 · 28.3%High 4 · 6.7%

Steroid plus vitamin D vs steroids

Number of participants achieving 'response' by PGA · scalp psoriasis

Steroid plus vitamin D leads to higher number of participants achieving 'response' by PGA compared with steroid (high certainty).

1 finding from 1 review

Steroid plus vitamin D vs steroids

Number of participants achieving 'clearance' by IGA · scalp psoriasis

Steroid plus vitamin D probably leads to higher number of participants achieving 'clearance' by IGA compared with steroid (moderate certainty).

1 finding from 1 review

Steroid plus vitamin D vs steroids

Number of participants achieving 'response' by IGA · scalp psoriasis

Steroid plus vitamin D probably leads to higher number of participants achieving 'response' by IGA compared with steroid (moderate certainty).

1 finding from 1 review

Steroid plus vitamin D vs steroids

Number of participants withdrawing due to adverse events (AE) · scalp psoriasis

Steroid plus vitamin D showed no clear difference in number of participants withdrawing due to adverse events (AE) compared with steroid (moderate certainty).

1 finding from 1 review

Topical vitamin D derivative vs placebo

Proportion of participants with adverse effects ‐ measured over 8 weeks · chronic palmoplantar pustulosis

Topical vitamin D derivative showed no clear difference in proportion of participants with adverse effects ‐ measured over 8… compared with placebo (moderate certainty).

1 finding from 1 review

Topical vitamin D derivative vs placebo

Proportion of participants cleared or almost cleared ‐ · chronic palmoplantar pustulosis

Topical vitamin D derivative may leads to higher proportion of participants cleared or almost cleared in the short… compared with placebo (low certainty).

1 finding from 1 review

Azithromycin vs placebo or vitamins

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Azithromycin vs placebo or vitamins

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

Azithromycin showed no clear difference in the proportion of participants with resolution of itch within 2… compared with placebo or vitamins (moderate certainty).

1 finding from 1 review

Azithromycin vs placebo or vitamins

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea

Azithromycin showed no clear difference in the proportion of participants with good or excellent rash… compared with placebo or vitamins (low certainty).

1 finding from 1 review