Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

52 questions · 52 findings · 8 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 16 · 30.8%GRADE not reported 5 · 9.6%Very low 8 · 15.4%Low 8 · 15.4%Moderate 15 · 28.8%High 0 · 0%

Single foetal haemoglobin inducer at any dose or duration vs placebo or usual care

Adverse events · people with non‐transfusion‐dependent β‐thalassaemia

It is very uncertain whether single foetal haemoglobin inducer at any dose or duration changes adverse events compared with usual care or placebo (very low certainty).

1 finding from 1 review

Digital technology vs usual care

Exacerbations (number of people experiencing ≥ 1 exacerbations) · adolescents and adults with cystic fibrosis

Digital technology showed no clear difference in number of pulmonary exacerbations: number of participants… compared with usual care (moderate certainty).

1 finding from 1 review

Digital technology vs usual care

New micro‐organisms: number of participants in whom new organisms are detected · adolescents and adults with cystic fibrosis

Digital technology probably leads to lower new micro‐organisms: number of participants in whom new organisms… compared with usual care (moderate certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Number of minor postoperative bleeding episodes · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions

The review found no eligible studies for this question.

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Outcome not reported · People with Von Willebrand disease undergoing minor oral surgery or dental extractions

The review found no eligible studies for this question.

1 finding from 1 review