What do systematic reviews say?

Oral tetracycline vs topical clindamycin

• Interventions for hidradenitis suppurativa 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 34 participants
  Low

Tetracycline + SRP vs SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD -0.53 [-1.14, 0.08]
  1 study · 38 participants
  GRADE not reported

Tetracycline + SRP vs SRP

Tetracycline + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD -1.90 [-2.17, -1.63]
  1 study · 26 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  MD -2.30 [-2.50, -2.10]
  1 study · 26 participants
  Very low
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD -0.92 [-2.38, 0.54]
  2 studies · 64 participants
  GRADE not reported

Tetracycline + SRP vs SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

Tetracycline + SRP vs SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

Tetracycline + SRP vs SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included study has not reported adverse events
  Studies not reported
  No studies found

Tetracycline + SRP vs SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD -14.62 [-27.21, -2.03]
  1 study · 38 participants
  GRADE not reported

Tetracycline + SRP vs SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

Macrolide+tetracycline vs macrolides

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 187 participants
  Very low

Macrolide+tetracycline vs macrolides

It is very uncertain whether macrolide+tetracycline changes all‐cause serious adverse events 60 weeks (end of study) compared with macrolide (very low certainty).

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  OR 1 [0.52, 1.93]
  1 study · 198 participants
  Very low

Macrolide+tetracycline vs macrolides

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 182 participants
  Very low

Macrolide+tetracycline vs macrolides

It is very uncertain whether macrolide+tetracycline changes all‐cause mortality 60 weeks (end of study) compared with macrolide (very low certainty).

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  OR 1.63 [0.38, 7.02]
  1 study · 198 participants
  Very low

Macrolide+tetracycline vs macrolides

The review found no eligible studies for this question.

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Nicotinamide plus tetracycline vs prednisone

It is very uncertain whether nicotinamide plus tetracycline changes disease control: complete response at 8 weeks: excluding dropouts compared with prednisone (very low certainty).

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  RR 2.5 [0.37, 16.89]
  1 study · 18 participants
  Very low

Nicotinamide plus tetracycline vs prednisone

It is very uncertain whether nicotinamide plus tetracycline changes mortality at 6 months compared with prednisone (very low certainty).

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  RR 0.18 [0.01, 3.85]
  1 study · 18 participants
  Very low

Nicotinamide plus tetracycline vs prednisone

The review found no eligible studies for this question.

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Nicotinamide plus tetracycline vs prednisone

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Macrolides vs tetracycline

Macrolide showed no clear difference in number of participants experiencing one or more exacerbations… compared with tetracycline (low certainty).

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  OR 0.44 [0.14, 1.38]
  1 study · 50 participants
  Low

Quinolone vs tetracycline

Quinolone showed no clear difference in number of participants experiencing one or more exacerbations… compared with tetracycline (low certainty).

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  OR 0.44 [0.14, 1.38]
  1 study · 50 participants
  Low

Tetracycline suspension (250 mg, held in mouth 2 minutes then swallowed, four times daily for 5 days) vs placebo

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  5 days per outbreak
  A statistically significant difference was shown, in favour of tetracycline, for adjusted maximum ulcer size (P=0.034) and adjusted maximum pain (P=0.017).
  1 study
  GRADE not reported