Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

42 questions · 42 findings · 2 reviews · Haematology

No studies found 23 · 54.8%GRADE not reported 0 · 0%Very low 18 · 42.9%Low 1 · 2.4%Moderate 0 · 0%High 0 · 0%

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

Quality of life ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs alternative haemostatic agents

Number of transfusions per participant within 7 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs alternative haemostatic agents

Serious adverse events measured by plasma transfusion‐related complications within 24 hours № of participants: 21 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether prophylactic plasma transfusion before surgery/invasive procedures changes serious adverse events measured by plasma transfusion‐related… compared with alternative haemostatic agents (very low certainty).

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs alternative haemostatic agents

All‐cause mortality up to 30 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs alternative haemostatic agents

Bleeding ‐ major/excessive · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether prophylactic plasma transfusion before surgery/invasive procedures changes major bleeding within 24 hours № of participants: 21 (1 RCT) compared with alternative haemostatic agents (very low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Serious adverse events measured by surgery or procedure‐related complications within 30 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic platelet transfusion prior to surgery vs alternative treatment

Serious adverse events (transfusion‐related adverse effects within 24 hours of the transfusion) · people with a low platelet count

It is very uncertain whether prophylactic platelet transfusion prior to surgery changes serious adverse events (transfusion‐related adverse effects within… compared with alternative treatments (very low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Major bleeding · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether thromboelastography threshold changes major bleeding within 24 hours № of participants: 60 (1 RCT) compared with standard of care (laboratory parameters) (very low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Number of individuals requiring a transfusion within 7 days № of participants: 60 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

Thromboelastography threshold may leads to lower number of individuals requiring a transfusion within 7 days № of… compared with standard of care (laboratory parameters) (low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Serious adverse events measured by plasma transfusion‐related complications within 24 hours № of participants: 21 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether thromboelastography threshold changes serious adverse events measured by plasma transfusion‐related… compared with standard of care (laboratory parameters) (very low certainty).

1 finding from 1 review