Disease-free survival · women with stage IIIc or IV ovarian cancer
It is very uncertain whether ultra‐radical (extensive) surgery changes disease‐free survival compared with standard surgery (very low certainty).
1 finding from 1 review
Rate of optimal cytoreduction · women with stage IIIc or IV ovarian cancer
1 finding from 1 review
no estimate extracted
Studies not reported
High
Recurrence · women with stage IIIc or IV ovarian cancer
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
(Loco)regional control · women with stage IIIc or IV ovarian cancer
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Perioperative mortality · women with stage IIIc or IV ovarian cancer
It is very uncertain whether ultra‐radical (extensive) surgery changes adverse event: perioperative mortality compared with standard surgery (very low certainty).
1 finding from 1 review
Adverse event: serious postoperative morbidity · women with stage IIIc or IV ovarian cancer
It is very uncertain whether ultra‐radical (extensive) surgery changes adverse event: serious postoperative morbidity compared with standard surgery (very low certainty).
1 finding from 1 review
Quality of life · women with stage IIIc or IV ovarian cancer
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Overall survival · people with single or solitary brain metastasis
It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes overall survival compared with stereotactic radiosurgery (very low certainty).
1 finding from 1 review
Health‐related quality of life (HRQoL) · people with single or solitary brain metastasis
1 finding from 1 review
Adverse events · people with single or solitary brain metastasis
It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events compared with stereotactic radiosurgery (very low certainty).
1 finding from 1 review
Adverse events (moderate) · people with single or solitary brain metastasis
It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (moderate) compared with stereotactic radiosurgery (very low certainty).
1 finding from 1 review
Adverse events (severe) · people with single or solitary brain metastasis
It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (severe) compared with stereotactic radiosurgery (very low certainty).
1 finding from 1 review
Progression‐free survival ‐ not measured · people with single or solitary brain metastasis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Health‐related quality of life (HRQoL) · people with single or solitary brain metastasis
1 finding from 1 review
no estimate extracted
1 study · 1 participants
Very low
Overall survival · people with single or solitary brain metastasis
Surgery plus whole brain radiotherapy (WBRT) showed no clear difference in overall survival compared with stereotactic radiosurgery plus WBRT (low certainty).
1 finding from 1 review
Adverse events (moderate) · people with single or solitary brain metastasis
It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (moderate) compared with stereotactic radiosurgery plus WBRT (very low certainty).
1 finding from 1 review
Progression‐free survival · people with single or solitary brain metastasis
Surgery plus whole brain radiotherapy (WBRT) showed no clear difference in progression‐free survival compared with stereotactic radiosurgery plus WBRT (low certainty).
1 finding from 1 review
Overall survivalNo. of participants: 2631(8 RCTs) · patients with newly diagnosed multiple brain metastases
Radiosurgery alone showed no clear difference in overall survivalNo. of participants: 403(3 RCTs) compared with WBRT and radiosurgery (moderate certainty).
1 finding from 1 review
HR 1 [0.8, 1.25]
Studies not reported
Moderate
1‐Year distant brain controlNo. of participants: 602(4 RCTs) · patients with newly diagnosed multiple brain metastases
Radiosurgery alone leads to higher 1‐Year distant brain controlNo. of participants: 602(4 RCTs) compared with WBRT and radiosurgery (high certainty).
1 finding from 1 review
HR 2.34 [1.73, 3.18]
Studies not reported
High
Adverse effectsNo. of participants: 1754(9 RCTs) · patients with newly diagnosed multiple brain metastases
1 finding from 1 review
no estimate extracted
Studies not reported
High