What do systematic reviews say?

IUI in a stimulated cycle vs TI

• Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

IUI in a stimulated cycle vs TI

IUI in stimulated cycles showed no clear difference in multiple pregnancy rate per couple compared with TI (low certainty).

• Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
  OR 3.15 [0.12, 79.69]
  Studies not reported
  Low

IUI in a stimulated cycle vs TI

IUI in stimulated cycles showed no clear difference in miscarriage rate per couple compared with TI (low certainty).

• Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
  OR 1.03 [0.19, 5.42]
  Studies not reported
  Low

IUI in a stimulated cycle vs TI or expectant management

It is very uncertain whether IUI in a stimulated cycle changes ovarian hyperstimulation syndrome rate per woman compared with TI or expectant management (very low certainty).

• Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
  OR 2.75 [0.11, 69.83]
  1 study · 68 participants
  Very low
• Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

IUI in a stimulated cycle vs TI or expectant management

IUI in a stimulated cycle showed no clear difference in miscarriage rate per couple compared with TI or expectant management (low certainty).

• Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
  OR 1.66 [0.56, 4.88]
  2 studies · 208 participants
  Low
• Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
  OR 2.87 [1.18, 7.01]
  2 studies · 454 participants
  Moderate

IUI in a stimulated cycle vs TI or expectant management

IUI in a stimulated cycle showed no clear difference in ectopic pregnancy rate per couple compared with TI or expectant management (low certainty).

• Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
  OR 3.06 [0.12, 76.95]
  1 study · 100 participants
  Low
• Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
  OR 9.28 [0.49, 174.6]
  1 study · 201 participants
  Low

IUI in a stimulated cycle vs TI or expectant management

IUI in a stimulated cycle showed no clear difference in multiple pregnancy rate per couple compared with TI or expectant management (low certainty).

• Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
  OR 3.01 [0.47, 19.28]
  2 studies · 454 participants
  Low
• Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
  OR 1.46 [0.55, 3.87]
  4 studies · 316 participants
  Low

IUI in a stimulated cycle vs IUI

IUI in a stimulated cycle showed no clear difference in multiple pregnancy rate per couple compared with IUI (low certainty).

• Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
  OR 3 [0.11, 78.27]
  1 study · 39 participants
  Low

IUI in a stimulated cycle vs IUI

The review found no eligible studies for this question.

• Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

IUI in a stimulated cycle vs IUI

IUI in a stimulated cycle showed no clear difference in miscarriage rate per couple compared with IUI (low certainty).

• Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
  OR 5.21 [0.19, 141.08]
  1 study · 26 participants
  Low

IUI in a stimulated cycle vs IUI

It is very uncertain whether IUI in a stimulated cycle changes ectopic pregnancy rate per couple compared with IUI (very low certainty).

• Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
  OR 6.48 [0.33, 127.09]
  1 study · 211 participants
  Very low

Double intrauterine insemination (IUI) vs single IUI

Double intrauterine insemination (IUI) showed no clear difference in live birth ratea compared with single IUI (low certainty).

• Double versus single intrauterine insemination (IUI) in stimulated cycles for subfertile couples 2021 · Cochrane Headline outcomes only
  OR 1.15 [0.71, 1.88]
  3 studies · 468 participants
  Low

Double intrauterine insemination (IUI) vs single IUI

Double intrauterine insemination (IUI) showed no clear difference in miscarriage ratea compared with single IUI (low certainty).

• Double versus single intrauterine insemination (IUI) in stimulated cycles for subfertile couples 2021 · Cochrane Headline outcomes only
  OR 1.78 [0.98, 3.24]
  6 studies · 2363 participants
  Low

Double intrauterine insemination (IUI) vs single IUI

Double intrauterine insemination (IUI) may leads to higher clinical pregnancy ratea compared with single IUI (low certainty).

• Double versus single intrauterine insemination (IUI) in stimulated cycles for subfertile couples 2021 · Cochrane Headline outcomes only
  OR 1.51 [1.23, 1.86]
  9 studies · 2716 participants
  Low

Double intrauterine insemination (IUI) vs single IUI

Double intrauterine insemination (IUI) showed no clear difference in multiple pregnancy ratea compared with single IUI (low certainty).

• Double versus single intrauterine insemination (IUI) in stimulated cycles for subfertile couples 2021 · Cochrane Headline outcomes only
  OR 2.04 [0.91, 4.56]
  5 studies · 2203 participants
  Low

Double intrauterine insemination (IUI) vs single IUI

Double intrauterine insemination (IUI) showed no clear difference in ectopic pregnancy ratea compared with single IUI (low certainty).

• Double versus single intrauterine insemination (IUI) in stimulated cycles for subfertile couples 2021 · Cochrane Headline outcomes only
  OR 1.22 [0.35, 4.28]
  4 studies · 1048 participants
  Low

Monitoring ovarian stimulation by transvaginal ultrasound (TVUS) only vs monitoring with TVUS plus serum estradiol

Monitoring ovarian stimulation by transvaginal ultrasound (TVUS) only showed no clear difference in cycle cancellation rate per woman compared with monitoring with TVUS plus serum estradiol (low certainty).

• Monitoring of stimulated cycles in assisted reproduction (IVF and ICSI) 2021 · Cochrane Headline outcomes only
  OR 0.57 [0.07, 4.39]
  2 studies · 115 participants
  Low

Monitoring ovarian stimulation by transvaginal ultrasound (TVUS) only vs monitoring with TVUS plus serum estradiol

The review found no eligible studies for this question.

• Monitoring of stimulated cycles in assisted reproduction (IVF and ICSI) 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Monitoring ovarian stimulation by transvaginal ultrasound (TVUS) only vs monitoring with TVUS plus serum estradiol

Monitoring ovarian stimulation by transvaginal ultrasound (TVUS) only showed no clear difference in clinical pregnancy per woman compared with monitoring with TVUS plus serum estradiol (low certainty).

• Monitoring of stimulated cycles in assisted reproduction (IVF and ICSI) 2021 · Cochrane Headline outcomes only
  OR 1.1 [0.79, 1.54]
  4 studies · 617 participants
  Low

Monitoring ovarian stimulation by transvaginal ultrasound (TVUS) only vs monitoring with TVUS plus serum estradiol

• Monitoring of stimulated cycles in assisted reproduction (IVF and ICSI) 2021 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 595 participants
  Low