Findings

What do systematic reviews say?

29 questions · 29 findings · 4 reviews · Heart

No studies found 0 · 0%GRADE not reported 3 · 10.3%Very low 4 · 13.8%Low 14 · 48.3%Moderate 8 · 27.6%High 0 · 0%

HDL‐C (mg/dL) · people with hyperlipidaemia

1 finding from 1 review

Chronotherapy versus conventional statins therapy for the treatment of hyperlipidaemia 2016 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 514 participants
Low

Triglycerides (mg/dL) · people with hyperlipidaemia

1 finding from 1 review

Chronotherapy versus conventional statins therapy for the treatment of hyperlipidaemia 2016 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 510 participants
Low

Mean pressure gradient (mmHg) Better indicated by lower scores. · patients with aortic valve stenosis

Statin showed no clear difference in mean pressure gradient (mmHg) Better indicated by lower scores. compared with placebo (low certainty).

1 finding from 1 review

Statins for aortic valve stenosis 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1935 participants
Low

Valve area (cm2) Better indicated by higher scores. · patients with aortic valve stenosis

Statin showed no clear difference in valve area (cm2) Better indicated by higher scores. compared with placebo (low certainty).

1 finding from 1 review

Statins for aortic valve stenosis 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 127 participants
Low

Aortic jet velocity (m/s) · patients with aortic valve stenosis

Statin showed no clear difference in aortic jet velocity (m/s) compared with placebo (low certainty).

1 finding from 1 review

Statins for aortic valve stenosis 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 155 participants
Low

Freedom from valve replacement · patients with aortic valve stenosis

Statin showed no clear difference in freedom from valve replacement compared with placebo (moderate certainty).

1 finding from 1 review

Statins for aortic valve stenosis 2016 · Cochrane Headline outcomes only
RR 0.93 [0.81, 1.06]
4 studies · 2360 participants
Moderate

All cardiovascular death · patients with aortic valve stenosis

Statin showed no clear difference in death from cardiovascular cause compared with placebo (low certainty).

1 finding from 1 review

Statins for aortic valve stenosis 2016 · Cochrane Headline outcomes only
RR 0.8 [0.56, 1.15]
3 studies · 2297 participants
Low

Hospitalisation for any reason · patients with aortic valve stenosis

It is very uncertain whether statin changes hospitalisation for any reason compared with placebo (very low certainty).

1 finding from 1 review

Statins for aortic valve stenosis 2016 · Cochrane Headline outcomes only
RR 0.84 [0.39, 1.84]
1 study · 155 participants
Very low

Adverse events ‐ Muscle pain · patients with aortic valve stenosis

Statin showed no clear difference in adverse events ‐ Muscle pain compared with placebo (moderate certainty).

1 finding from 1 review

Statins for aortic valve stenosis 2016 · Cochrane Headline outcomes only
RR 0.91 [0.75, 1.09]
3 studies · 2204 participants
Moderate