Findings

What do systematic reviews say?

33 questions · 33 findings · 3 reviews · Common Mental Disorders

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No studies found 0 · 0%GRADE not reported 3 · 9.1%Very low 8 · 24.2%Low 7 · 21.2%Moderate 15 · 45.5%High 0 · 0%

Intervention not reported

mirtazapine:sertraline · children and/or adolescents with depression

1 finding from 1 review

New generation antidepressants for depression in children and adolescents: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Paroxetine vs sertraline

Failure to respond at endpoint (6‐12 weeks) · patients with depression

Paroxetine showed no clear difference in failure to respond at endpoint (6‐12 weeks) compared with sertraline (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.25 [0.89, 1.77]
3 studies · 618 participants
Moderate

Paroxetine vs sertraline

Failure to respond at 1‐4 weeks · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Paroxetine vs sertraline

Failure to respond at 16‐24 weeks · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Paroxetine vs sertraline

Failure to remit at endpoint · patients with depression

Paroxetine showed no clear difference in failure to remit at endpoint compared with sertraline (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 0.94 [0.67, 1.34]
2 studies · 545 participants
Moderate

Paroxetine vs sertraline

SMD at endpoint · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 353 participants
Moderate

Paroxetine vs sertraline

Failure to complete ‐ any cause ‐ · patients with depression

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with sertraline (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.37 [0.52, 3.6]
2 studies · 426 participants
Moderate

Paroxetine vs sertraline

Participants with at least some Side Effects · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Fluoxetine vs sertraline

Failure to respond (reduction ≥ 50% on HDRS) · patients with depression

Fluoxetine probably leads to higher failure to respond (reduction ≥ 50% on HDRS) compared with sertraline (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.37 [1.08, 1.74]
6 studies · 1188 participants
Moderate

Fluoxetine vs sertraline

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1160 participants
Moderate

Fluoxetine vs sertraline

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with sertraline (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.17 [0.93, 1.49]
9 studies · 1591 participants
Moderate

Fluoxetine vs sertraline

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with sertraline (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.09 [0.68, 1.77]
5 studies · 1056 participants
Moderate

Fluoxetine vs sertraline

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with sertraline (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.25 [0.92, 1.7]
9 studies · 1591 participants
Moderate