Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

43 questions · 43 findings · 2 reviews · Skin

No studies found 14 · 32.6%GRADE not reported 0 · 0%Very low 14 · 32.6%Low 13 · 30.2%Moderate 2 · 4.7%High 0 · 0%

Azelaic acid vs tretinoin

Participants' global self‐assessment of acne improvement Good to excellent improvement (long term: treatment duration > 8 weeks) · participants with acne

Azelaic acid showed no clear difference in participants' global self‐assessment of acne improvement Good to… compared with tretinoin (moderate certainty).

1 finding from 1 review

Azelaic acid vs benzoyl peroxide

Participants' global self‐assessment of acne improvement Good or very good improvement (long term: treatment duration > 8 weeks) · participants with acne

Azelaic acid probably leads to lower participants' global self‐assessment of acne improvement Good or… compared with benzoyl peroxide (moderate certainty).

1 finding from 1 review

Azelaic acid vs clindamycin

Participants' global self‐assessment of acne improvement Good or very good improvement (long term: treatment duration > 8 weeks) · participants with acne

Azelaic acid showed no clear difference in participants' global self‐assessment of acne improvement Good or… compared with clindamycin (low certainty).

1 finding from 1 review

Benzoyl peroxide vs salicylic acid

Participant's global self‐assessment of improvement (long‐term data) ‐ not measured · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Benzoyl peroxide vs salicylic acid

Adverse effect/event: 2. Adverse effects ‐ any ‐ medium‐termonly · participants with acne

It is very uncertain whether benzoyl peroxide changes total number of participants with any adverse events (medium‐term… compared with salicylic acid (very low certainty).

1 finding from 1 review

Nicotinamide vs clindamycin

Withdrawal for any reason (medium term: treatment duration from 5 to 8 weeks) · participants with acne

Nicotinamide showed no clear difference in withdrawal for any reason (medium term: treatment duration from 5 to… compared with clindamycin (low certainty).

1 finding from 1 review