Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

47 questions · 47 findings · 2 reviews

No studies found 16 · 34%GRADE not reported 2 · 4.3%Very low 4 · 8.5%Low 19 · 40.4%Moderate 5 · 10.6%High 1 · 2.1%

Prostanoids vs lumbar sympathectomy

Quality of life at post‐treatment Indexed by self‐report measures of quality of life or functional disability · people with critical limb ischaemia due to non‐reconstructable peripheral arterial disease

The review found no eligible studies for this question.

1 finding from 1 review

PGE1 vs ATP

Cardiovascular mortality · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

PGE1 vs ATP

Amputation · people with critical limb ischaemia

PGE1 may leads to lower total amputations compared with ATP (low certainty).

1 finding from 1 review

PGE1 vs ATP

Quality of life · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

PGE1 vs ATP

Adverse event (participants) · people with critical limb ischaemia

PGE1 may leads to higher adverse event (participants) compared with ATP (low certainty).

1 finding from 1 review

PGE1 vs ATP

Ulcer healing (complete) · people with critical limb ischaemia

PGE1 showed no clear difference in ulcer healing (complete) compared with ATP (low certainty).

1 finding from 1 review

PGE1 vs inositol niacinate

Adverse events (participants) · people with critical limb ischaemia

PGE1 showed no clear difference in adverse events (participants) compared with inositol niacinate (low certainty).

1 finding from 1 review

PGE1 vs inositol niacinate

Rest‐pain relief · people with critical limb ischaemia

PGE1 showed no clear difference in rest‐pain relief compared with inositol niacinate (low certainty).

1 finding from 1 review

PGE1 vs inositol niacinate

Ulcer healing · people with critical limb ischaemia

PGE1 showed no clear difference in ulcer healing compared with inositol niacinate (low certainty).

1 finding from 1 review

Iloprost vs PGE1

Cardiovascular mortality · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

Iloprost vs PGE1

Amputation · people with critical limb ischaemia

Iloprost showed no clear difference in total amputations compared with PGE1 (low certainty).

1 finding from 1 review

Iloprost vs PGE1

Quality of life · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

Iloprost vs PGE1

Adverse events (participants) · people with critical limb ischaemia

Iloprost probably leads to higher adverse events (participants) compared with PGE1 (moderate certainty).

1 finding from 1 review

Iloprost vs PGE1

Rest‐pain relief · people with critical limb ischaemia

Iloprost showed no clear difference in rest‐pain relief compared with PGE1 (low certainty).

1 finding from 1 review