Findings

What do systematic reviews say?

1,368 questions · 1,413 findings · 89 reviews · Common Mental Disorders

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No studies found 232 · 16.4%GRADE not reported 82 · 5.8%Very low 395 · 28%Low 331 · 23.4%Moderate 341 · 24.1%High 32 · 2.3%

Antidepressants vs placebo

Change in depression severity from baseline · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs placebo

Improvement in depression at 6‐12 weeks: HAM‐D score (continuous) · adults living with HIV and depression

1 finding from 1 review

Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 357 participants
Low

Antidepressants vs placebo

Improvement in depression at 6‐12 weeks: HAM‐D score (dichotomized) · adults living with HIV and depression

Antidepressant showed no clear difference in improvement in depression: HAM‐D score at 6‐12 weeks (dichotomized) compared with placebo (low certainty).

1 finding from 1 review

Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
RR 1.1 [0.89, 1.35]
5 studies · 434 participants
Low

Antidepressants vs placebo

Improvement in depression at 6‐12 weeks: CGI‐I (score of 1 or 2) · adults living with HIV and depression

Antidepressant showed no clear difference in improvement in depression at 6‐12 weeks: CGI‐I (score of 1 or 2) compared with placebo (low certainty).

1 finding from 1 review

Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
RR 1.28 [0.93, 1.77]
4 studies · 346 participants
Low

Antidepressants vs placebo

Adverse effects during antidepressant treatment period (0‐12 weeks) · adults living with HIV and depression

It is very uncertain whether antidepressant changes adverse effects during antidepressant treatment period (0‐12 weeks) compared with placebo (very low certainty).

1 finding from 1 review

Antidepressants for depression in adults with HIV infection 2018 · Cochrane Headline outcomes only
RR 0.88 [0.64, 1.21]
2 studies · 167 participants
Very low

Tricylic antidepressant vs placebo

Change in depressive symptoms · chronic obstructive pulmonary disease (COPD) with depression

1 finding from 1 review

Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Second generation antidepressant vs placebo medication

Depressive disorder according to DSM or ICD criteriaClinician diagnostic interview · patients with depressive disorders in children and adolescents

1 finding from 1 review

Newer generation antidepressants for depressive disorders in children and adolescents 2012 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Second generation antidepressant vs placebo medication

Depressive symptoms · patients with depressive disorders in children and adolescents

1 finding from 1 review

Newer generation antidepressants for depressive disorders in children and adolescents 2012 · Cochrane Headline outcomes only
no estimate extracted
14 studies · 2490 participants
Low

Antidepressant plus antipsychotic vs placebo

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes clinical response of depression compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 1.86 [1.23, 2.82]
2 studies · 148 participants
Very low

Antidepressant plus antipsychotic vs placebo

Depression remission · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressant plus antipsychotic vs placebo

Change in depression severity from baseline · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressant plus antipsychotic vs placebo/no adjunctive treatment + antipsychotics

Clinical response of depression · adults with psychotic depression

Antidepressant plus antipsychotic may leads to higher clinical response of depression compared with placebo plus antipsychotic (low certainty).

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 1.83 [1.4, 2.38]
4 studies · 447 participants
Low

Antidepressant plus antipsychotic vs placebo/no adjunctive treatment + antipsychotics

Depression remission · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressant plus antipsychotic vs placebo/no adjunctive treatment + antipsychotics

Change in depression severity from baseline · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Successful discontinuation rate · participants with long‐term antidepressants for depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 146 participants
Low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Depressive symptoms · participants with long‐term antidepressants for depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 106 participants
Low

Intervention not reported

Suicide (Observation period ‐ pre‐intervention: 119.5 years; postintervention: 92 years) · adults or children of all ethnicities

The intervention may leads to lower suicide (Observation period ‐ pre‐intervention: 119.5 years;… (low certainty).

1 finding from 1 review

Means restriction for the prevention of suicide by jumping 2020 · Cochrane Headline outcomes only
IRR 0.09
12 participants
Low

Intervention not reported

Suicide (Observation period: pre‐intervention 30.5 years; postintervention 13.5 years) · adults or children of all ethnicities

The intervention may leads to lower suicide (Observation period: pre‐intervention 30.5 years;… (low certainty).

1 finding from 1 review

Means restriction for the prevention of suicide by jumping 2020 · Cochrane Headline outcomes only
IRR 0.54
3 studies · 3 participants
Low

Intervention not reported

Suicide (Observation period: pre‐intervention 81.5 years; postintervention 71.8 years) · adults or children of all ethnicities

The intervention may leads to lower suicide (Observation period: pre‐intervention 81.5 years;… (low certainty).

1 finding from 1 review

Means restriction for the prevention of suicide by jumping 2020 · Cochrane Headline outcomes only
IRR 0.07
7 studies · 7 participants
Low

Intervention not reported

Suicide (Observation period: pre‐intervention 19.5 years; postintervention 6.5 years) · adults or children of all ethnicities

The intervention may leads to lower suicide (Observation period: pre‐intervention 19.5 years;… (low certainty).

1 finding from 1 review

Means restriction for the prevention of suicide by jumping 2020 · Cochrane Headline outcomes only
IRR 0.09
2 studies · 2 participants
Low