Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

625 questions · 647 findings · 67 reviews · Pregnancy and Childbirth

No studies found 83 · 12.8%GRADE not reported 70 · 10.8%Very low 141 · 21.8%Low 227 · 35.1%Moderate 97 · 15%High 29 · 4.5%

Magnesium sulphate vs placebo (outcomes

Severe maternal outcome potentially related to treatment (death, respiratory arrest, or cardiac arrest)** · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in severe maternal outcome potentially related to treatment (death,… compared with placebo (outcomes (low certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Cerebral palsy · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate leads to lower cerebral palsy (up to 2 years' corrected age)** compared with placebo (outcomes (high certainty).

2 findings from 1 review

Magnesium sulphate vs placebo (outcomes

Major disability by 18 to 24 months corrected age (aligned definition) · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in major neurodevelopmental disability (up to 2 years' corrected age)** compared with placebo (outcomes (moderate certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Intraventricular haemorrhage, Papile grade 3/4 · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate probably leads to lower severe intraventricular haemorrhage (grade 3 or 4) (newborn/infant)** compared with placebo (outcomes (moderate certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Bronchopulmonary dysplasia/chronic lung disease · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in chronic lung disease/bronchopulmonary dysplasia (newborn/infant)** compared with placebo (outcomes (low certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Death (fetal, neonatal, or later (up to school age))** · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in death (fetal, neonatal, or later (up to school age))** compared with placebo (outcomes (low certainty).

1 finding from 1 review

Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Maternal anaemia · pregnant women

It is very uncertain whether summary of findings table ‐ Vitamin B12 supplementation changes maternal anaemia compared with placebo/no vitamin B12 supplementation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Maternal vitamin B12 deficiency · pregnant women

It is very uncertain whether summary of findings table ‐ Vitamin B12 supplementation changes maternal vitamin B12 deficiency compared with placebo/no vitamin B12 supplementation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Low birthweight · pregnant women

Summary of findings table ‐ Vitamin B12 supplementation showed no clear difference in low birthweight (< 2500 g) compared with placebo/no vitamin B12 supplementation (low certainty).

1 finding from 1 review

Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Preterm birth · pregnant women

Summary of findings table ‐ Vitamin B12 supplementation showed no clear difference in preterm birth (< 37 weeks) compared with placebo/no vitamin B12 supplementation (low certainty).

1 finding from 1 review