Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,756 questions · 13,493 findings · 1,305 reviews · Headline outcomes only

No studies found 2,594 · 19.2%GRADE not reported 728 · 5.4%Very low 2,868 · 21.3%Low 3,777 · 28%Moderate 2,620 · 19.4%High 906 · 6.7%

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New‐generation antidepressants vs placebo

Repetition of SH at post‐intervention · self‐harm in adults

It is very uncertain whether newer generation antidepressants (NGAs) changes repetition of SH by post‐intervention (NGA class)№ of participants:… compared with placebo (very low certainty).

3 findings from 1 review

Estimates of effects, ranking, and certainty of evidence for different treatment options vs placebo

Placebo (4 RCT; 789 participants)
4 findings from 1 review
Show 1 more finding

Intervention not reported

Varenicline plus behavioral intervention vs placebo plus behavioral intervention ‐ (repeated point prevalence abstinence (not even a puff/chew/session in the last 7 days) at each of weeks 5, 12, and 25 (combined), verified by CO cutoff < 10 ppm) · people who use waterpipe

The intervention showed no clear difference in varenicline plus behavioral intervention vs placebo plus behavioral… (low certainty).

1 finding from 1 review