Treatment failure · neonates with possible serious bacterial infection
Comparison 2: 2 days injectable benzylpenicillin + injectable… showed no clear difference in treatment failure compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).
1 finding from 1 review
Adverse events · neonates with possible serious bacterial infection
Comparison 2: 2 days injectable benzylpenicillin + injectable… showed no clear difference in adverse events compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).
1 finding from 1 review
HIV seroconversion ‐ penicillin vs single‐dose azithromycin · patients with syphilis
1 finding from 1 review
HIV seroconversion ‐ penicillin vs two‐dose azithromycin · patients with syphilis
1 finding from 1 review
Fever clearance time · patients with treating septic abortion
1 finding from 1 review
Absence of fever during D&C (mean time) · patients with treating septic abortion
1 finding from 1 review
Incidence of S pneumoniae infection Isolated bacterial infection · children with SCD
Summary of findings ‐ initiation of penicillin prophylaxis may leads to lower incidence of S pneumoniae infection Isolated bacterial infection compared with placebo (low certainty).
1 finding from 1 review
Deaths · children with SCD
Summary of findings ‐ initiation of penicillin prophylaxis showed no clear difference in deaths compared with placebo (low certainty).
1 finding from 1 review
Adverse effects · children with SCD
1 finding from 1 review
Antibiotic‐resistant organisms isolated · children with SCD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Requirement of other courses of antibiotics · children with SCD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Compliance with treatment · children with SCD
1 finding from 1 review
Total number of ibuprofen tablets · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis
Systemic antibiotic (oral penicillin 500 mg) plus analgesic showed no clear difference in total number of ibuprofen tablets compared with placebo plus analgesic (low certainty).
1 finding from 1 review
Number of adverse events · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis
The review found no eligible studies for this question.
1 finding from 1 review
Patient-reported pain intensity (sum of pain intensity difference (SPID) and sum of pain percussion intensity difference (SPPID)) · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis
1 finding from 1 review
Corresponding risk (Antibiotics): The in between-group differences (median +/- IQR) in SPID for the penicillin group were 6.0 +/- 10.5, and for placebo 6.0 +/- 9.5. The SPPID for the penicillin group was 3.5 +/- 7.5…
1 study · 40 participants
Low
Total number of paracetamol (acetaminophen) with codeine (Tylenol) tablets · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis
Systemic antibiotic (oral penicillin 500 mg) plus analgesic showed no clear difference in total number of paracetamol (acetaminophen) with codeine (Tylenol)… compared with placebo plus analgesic (low certainty).
1 finding from 1 review
Relief of pain · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis
The review found no eligible studies for this question.
1 finding from 1 review
Number of ibuprofen tablets required · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
Postoperative systemic antibiotics… showed no clear difference in number of ibuprofen tablets required compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
1 finding from 1 review
Percussion pain at 24 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
Postoperative systemic antibiotics… showed no clear difference in percussion pain at 24 hours compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
2 findings from 1 review
Pain at 24 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
It is very uncertain whether postoperative systemic antibiotics… changes pain at 24 hours compared with matched placebo, partial or total chemo-mechanical debridement and… (very low certainty).
1 finding from 1 review