Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

272 questions · 281 findings · 42 reviews · Headline outcomes only

No studies found 62 · 22.1%GRADE not reported 5 · 1.8%Very low 68 · 24.2%Low 100 · 35.6%Moderate 37 · 13.2%High 9 · 3.2%

Cyclamen europaeum vs placebo

Proportion of participants with any adverse event · adults with acute sinusitis

Cyclamen europaeum probably leads to higher proportion of participants with any adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Human recombinant activated protein C vs placebo

28‐Day all‐cause mortality (adult and paediatric patients) · patients with severe sepsis or septic shock

Human recombinant activated protein C showed no clear difference in 28‐Day all‐cause mortality (adult and paediatric patients) compared with placebo (moderate certainty).

1 finding from 1 review

Human recombinant activated protein C vs placebo

In‐hospital mortality (adult and paediatric patients) · patients with severe sepsis or septic shock

Human recombinant activated protein C showed no clear difference in in‐hospital mortality (adult and paediatric patients) compared with placebo (moderate certainty).

1 finding from 1 review

Human recombinant activated protein C vs placebo

Serious bleeding events in adult and paediatric patients (days 0 to 28) · patients with severe sepsis or septic shock

Human recombinant activated protein C probably leads to higher serious bleeding events in adult and paediatric patients (days 0 to… compared with placebo (moderate certainty).

1 finding from 1 review

Human recombinant activated protein C vs placebo

Serious adverse events (adult and paediatric patients) · patients with severe sepsis or septic shock

Human recombinant activated protein C showed no clear difference in serious adverse events (adult and paediatric patients) compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin

Antibiotic resistance: change from baseline in P aeruginosa CFU/g of sputum at week 24 · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
1 finding from 1 review

Band ligation vs no intervention or a sham procedure

Serious adverse events Idiopathic thrombocytopaenic purpura · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment

It is very uncertain whether band ligation changes serious adverse events Idiopathic thrombocytopaenic purpura compared with sham or no intervention (very low certainty).

1 finding from 1 review

Intervention not reported

PAE (mixed estimate) · men with moderate to severe lower urinary symptoms due to benign prostatic hyperplasia Interventions: minimally invasive treatments.…

It is very uncertain whether the intervention changes PAE (mixed estimate) (very low certainty).

1 finding from 1 review