Cochrane · systematic review · CD013656
Minimally invasive treatments for lower urinary tract symptoms in men with benign prostatic hyperplasia: a network meta‐analysis
Franco, JVA, Jung, JH, Imamura, M, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
UrologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
31
current version
GRADE rated
19
No studies
8
Included studies
NR
No studies 8 · 25.8%Ungraded 4 · 12.9%Very low 8 · 25.8%Low 11 · 35.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Urologic symptoms scores ‐ short term
Population: men with moderate to severe lower urinary symptoms due to benign prostatic hyperplasia Interventions: minimally invasive treatments Comparator (reference): transurethral resection of the prostate
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
studies 1847 participants | no estimate extracted | 19 studies · 1847 participants | Ungraded |
PUL (UroLift) (mixed estimate) | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
PAE (mixed estimate) | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
CRFWVT (Rezūm) (indirect estimate) | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
TUMT (mixed estimate) | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
TIND (indirect estimate) | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
Quality of life ‐ short term
Population: men with moderate to severe lower urinary symptoms due to benign prostatic hyperplasia Interventions: minimally invasive treatments Comparator (reference): transurethral resection of the prostate
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
studies 1469 participants | no estimate extracted | 13 studies · 1469 participants | Ungraded |
PUL (UroLift) (mixed estimate) | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
PAE (mixed estimate) | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
CRFWVT (Rezūm) (indirect estimate) | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
TUMT (mixed estimate) | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
TIND (indirect estimate) | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
Major adverse events
Population: men with moderate to severe lower urinary symptoms due to benign prostatic hyperplasia Interventions: minimally invasive treatments Comparator (reference): transurethral resection of the prostate
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
TUMT (mixed estimate) | no estimate extracted | NR | No studies |
TIND (indirect estimate) | no estimate extracted | NR | No studies |
PAE (mixed estimate) | no estimate extracted | NR | No studies |
Retreatment ‐ long term
Population: men with moderate to severe lower urinary symptoms due to benign prostatic hyperplasia Interventions: minimally invasive treatments. Comparator (reference): transurethral resection of the prostate
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
studies 799 participants | no estimate extracted | 10 studies · 799 participants | Ungraded |
PUL (UroLift) (mixed estimate) | RR 2.39 [0.51, 11.1] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
PAE (mixed estimate) | RR 4.39 [1.25, 15.44] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
TUMT (mixed estimate) | RR 9.71 [2.35, 40.13] | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
CRFWVT (Rezūm) (pairwise) | RR 1.36 | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
TIND (pairwise) | RR 0.67 | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Erectile function ‐ short term
Population: men with moderate to severe lower urinary symptoms due to benign prostatic hyperplasia Interventions: minimally invasive treatments. Comparator (reference): sham procedure or transurethral resection of the prostate
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
studies 640 participants | no estimate extracted | 6 studies · 640 participants | Ungraded |
CRFWVT (Rezūm) (indirect estimate) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision |
TIND (indirect estimate) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision |
PUL (UroLift) (mixed estimate) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision |
PAE (mixed estimate) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision |
TUMT | no estimate extracted | NR | No studies |
Ejaculatory function ‐ short term
Population: men with moderate to severe lower urinary symptoms due to benign prostatic hyperplasia Interventions: minimally invasive treatments Comparator (reference): transurethral resection of the prostate
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
TUMT (mixed estimate) | no estimate extracted | NR | No studies |
PAE (mixed estimate) | no estimate extracted | NR | No studies |
CRFWVT (Rezūm) (pairwise) | no estimate extracted | NR | No studies |
TIND (pairwise) | no estimate extracted | NR | No studies |