Findings

What do systematic reviews say?

27 questions · 27 findings · 3 reviews

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No studies found 4 · 14.8%GRADE not reported 17 · 63%Very low 3 · 11.1%Low 3 · 11.1%Moderate 0 · 0%High 0 · 0%

Topical triamcinolone acetonide vs Topical ciclosporin

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide led to lower adverse effects compared with topical ciclosporin; GRADE not reported.

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
end of treatment
RR 0.15 [0.05, 0.49]
1 study · 139 participants
GRADE not reported

Topical clobetasol propionate vs Topical ciclosporin

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical clobetasol propionate changes clinical resolution compared with topical ciclosporin (very low certainty).

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
3-8 weeks
RR 3.16 [1.00, 9.93]
1 study · 39 participants
Very low

Topical triamcinolone acetonide vs Topical ciclosporin

Pain (mean VAS score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in pain (mean VAS score) compared with topical ciclosporin; GRADE not reported.

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
end of treatment
MD -0.23 [-1.02, 0.56]
1 study · 139 participants
GRADE not reported

Topical clobetasol propionate vs Topical ciclosporin

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical clobetasol propionate changes adverse effects compared with topical ciclosporin (very low certainty).

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
3-8 weeks
RR 6.32 [0.84, 47.69]
1 study · 39 participants
Very low

0.1% triamcinolone acetonide in orabase vs ciclosporin

Physician Global Assessment (Thongprasom score) · People with erosive oral lichen planus

0.1% triamcinolone acetonide in orabase showed no clear difference in physician Global Assessment (Thongprasom score) compared with ciclosporin solution; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
MD 0.61 [-0.79, 2.01]
1 study · 11 participants
GRADE not reported

0.1% triamcinolone acetonide in orabase vs ciclosporin

Pain reduction (VAS 0-100) · People with erosive oral lichen planus

0.1% triamcinolone acetonide in orabase led to higher pain reduction (VAS 0-100) compared with ciclosporin solution; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
MD 45.17 [8.73, 81.61]
1 study · 11 participants
GRADE not reported

0.1% triamcinolone acetonide in orabase vs ciclosporin

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Yoke 2006: no significant adverse events; transient burning sensation upon initial application with both treatments.
1 study · 15 participants
GRADE not reported