Opioids vs other analgesics
Episodes of bradycardia · procedural pain in neonates
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Findings
What do systematic reviews say?
241 questions · 264 findings · 24 reviews
No studies found 84 · 31.8%GRADE not reported 5 · 1.9%Very low 83 · 31.4%Low 64 · 24.2%Moderate 21 · 8%High 7 · 2.7%
Opioids vs other analgesics
Hypotension · procedural pain in neonates
It is very uncertain whether opioids changes hypotension compared with other analgesics (very low certainty).
1 finding from 1 review
- RR 1.34 [0.32, 5.59]3 studies · 204 participantsVery low
Opioids vs other analgesics
Parent satisfaction with care provided in the NICU—not reported · procedural pain in neonates
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Opioids vs no treatment/placebo
Pain, assessed using the DAN pain scale, ranging from 0 to 21, 1 to 2 hours after procedure · procedural pain in neonates
1 finding from 1 review
- no estimate extracted1 study · 42 participantsLow
Opioids vs no treatment/placebo
Pain, assessed using the CRIES pain scale, ranging from 0 to 10, during the procedure— opioids versus facilitated tucking · procedural pain in neonates
1 finding from 1 review
- no estimate extracted2 studies · 102 participantsLow
Opioids vs no treatment/placebo
Any harms ‐ severe apnea requiring resuscitation · procedural pain in neonates
It is very uncertain whether opioids changes any harms ‐ severe apnea requiring resuscitation compared with no treatment/placebo (very low certainty).
1 finding from 1 review
- RR 7.44 [0.42, 132.95]1 study · 31 participantsVery low
Opioids vs no treatment/placebo
Episodes of bradycardia · procedural pain in neonates
It is very uncertain whether opioids changes episodes of bradycardia compared with no treatment/placebo (very low certainty).
1 finding from 1 review
- RR 3.19 [0.14, 72.69]3 studies · 172 participantsVery low
Opioids vs no treatment/placebo
Episodes of apnea · procedural pain in neonates
Opioids may leads to higher episodes of apnea compared with no treatment/placebo (low certainty).
1 finding from 1 review
- RR 3.15 [1.08, 9.16]3 studies · 199 participantsLow
Opioids vs no treatment/placebo
Hypotension · procedural pain in neonates
1 finding from 1 review
- no estimate extracted2 studies · 88 participantsVery low
Opioids vs placebo or no treatment
Pain (PIPP) · neonates with mechanical ventilation
1 finding from 1 review
- no estimate extracted3 studies · 963 participantsVery low
Opioids vs other analgesics and sedatives
Neonatal mortality · neonates with mechanical ventilation
It is very uncertain whether opioids changes neonatal mortality compared with other analgesics and sedatives (very low certainty).
1 finding from 1 review
- RR 0.31 [0.01, 7.16]1 study · 46 participantsVery low
Opioids vs other analgesics and sedatives
Mortality before hospital discharge · neonates with mechanical ventilation
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Opioids vs other analgesics and sedatives
Neurodevelopmental outcomes · neonates with mechanical ventilation
The review found no eligible studies for this question.
3 findings from 1 review
- no estimate extractedStudies not reportedNo studies found
- no estimate extractedStudies not reportedNo studies found
- no estimate extractedStudies not reportedNo studies found
Opioids vs placebo or no treatment
Duration of mechanical ventilation · neonates with mechanical ventilation
1 finding from 1 review
- no estimate extracted7 studies · 1259 participantsModerate
Opioids vs placebo or no treatment
Neonatal mortality · neonates with mechanical ventilation
Opioids showed no clear difference in neonatal mortality compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
- RR 1.12 [0.8, 1.55]5 studies · 1189 participantsModerate
Opioids vs placebo or no treatment
Mortality before hospital discharge · neonates with mechanical ventilation
Opioids showed no clear difference in mortality to discharge compared with placebo or no treatment (low certainty).
1 finding from 1 review
- RR 0.99 [0.52, 1.88]4 studies · 178 participantsLow
Opioids vs placebo or no treatment
Neurodevelopmental outcomes · neonates with mechanical ventilation
It is very uncertain whether opioids changes neurodevelopmental outcomes (18 to 24 months) compared with placebo or no treatment (very low certainty).
3 findings from 1 review
- RR 2 [0.39, 10.29]1 study · 78 participantsVery low
- no estimate extractedStudies not reportedNo studies found
- RR 1.6 [0.56, 4.56]1 study · 95 participantsVery low
Opioids vs other analgesics and sedatives
Pain (PIPP) · neonates with mechanical ventilation
1 finding from 1 review
- no estimate extracted1 study · 46 participantsVery low
Opioids vs other analgesics and sedatives
Duration of mechanical ventilation · neonates with mechanical ventilation
1 finding from 1 review
- no estimate extracted1 study · 46 participantsVery low
Opioids vs placebo
RLS symptoms · RLS
2 findings from 1 review
- no estimate extracted1 study · 270 participantsLow
- no estimate extracted1 study · 276 participantsLow