Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

103 questions · 111 findings · 10 reviews · Oral and maxillofacial surgery

No studies found 13 · 11.7%GRADE not reported 75 · 67.6%Very low 21 · 18.9%Low 2 · 1.8%Moderate 0 · 0%High 0 · 0%

Any experimental intervention (surgical or non-surgical) vs None (placebo or no treatment)

Mortality rate and cause of death · People of any age and either sex, in any setting, with BRONJ; bisphosphonate exposure past or current; includes people with cancer and…

The review found no eligible studies for this question.

1 finding from 1 review

Autogenous bone graft augmentation at the immediate implant site vs No augmentation

Vertical bone gain · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Autogenous bone graft augmentation at the immediate implant site showed no clear difference in bone gain (vertical - VDH) compared with no augmentation; GRADE not reported.

1 finding from 1 review

Autogenous bone graft augmentation at the immediate implant site vs No augmentation

Bone gain (horizontal - HDD) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Autogenous bone graft augmentation at the immediate implant site showed no clear difference in bone gain (horizontal - HDD) compared with no augmentation; GRADE not reported.

1 finding from 1 review

Autofluorescence-guided bone surgery vs Tetracycline fluorescence-guided bone surgery

Healing of MRONJ (mucosal integrity) · People with MRONJ referred for surgical treatment

It is very uncertain whether autofluorescence-guided bone surgery changes healing of MRONJ (mucosal integrity) compared with tetracycline fluorescence-guided bone surgery (very low certainty).

1 finding from 1 review

Bone morphogenetic protein-2 (BMP-2) together with platelet-rich fibrin vs Platelet-rich fibrin (PRF)

Healing of MRONJ · People with established (manifest) MRONJ

It is very uncertain whether bone morphogenetic protein-2 (BMP-2) together with platelet-rich… changes healing of MRONJ compared with platelet-rich fibrin alone (very low certainty).

1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - improvement ('healed' or 'improved' vs 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - improvement ('healed' or 'improved' vs… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review
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Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - healed ('healed' vs 'improved', 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - healed ('healed' vs 'improved',… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review
Show 2 more findings

Tranexamic acid (AMCA cones) vs Placebo (lactose cones)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Tranexamic acid (AMCA cones) showed no clear difference in presence of dry socket compared with placebo (lactose cones); GRADE not reported.

1 finding from 1 review

Resorbable barrier (guided bone regeneration) vs Resorbable barrier + particulate autogenous bone

Major complications at the implant/donor site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Resorbable barrier (guided bone regeneration) led to lower major complications at the implant/donor site compared with resorbable barrier + autogenous bone; GRADE not reported.

1 finding from 1 review

Resorbable barrier (guided bone regeneration) vs Non-resorbable barrier (guided bone regeneration)

Major complications at the implant/donor site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Resorbable barrier (guided bone regeneration) led to lower major complications at the implant/donor site compared with non-resorbable barrier (guided bone regeneration); GRADE not reported.

1 finding from 1 review

Non-resorbable barrier (guided bone regeneration) vs Resorbable barrier + particulate autogenous bone

Major complications at the implant/donor site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Non-resorbable barrier (guided bone regeneration) led to lower major complications at the implant/donor site compared with resorbable barrier + autogenous bone; GRADE not reported.

1 finding from 1 review

Neocone vs Alvogyl

Time to initial pain relief (minutes) · Adults (>18 years) with established dry socket following permanent tooth extraction

Neocone led to higher time to initial pain relief (minutes) compared with alvogyl; GRADE not reported.

1 finding from 1 review

Neocone vs Alvogyl

Mean time to resolution of pain · Adults (>18 years) with established dry socket following permanent tooth extraction

Neocone led to lower time to complete resolution of pain (days) compared with alvogyl; GRADE not reported.

1 finding from 1 review

Transbuccal miniplate combined with intraoral approach vs Intraoral approach alone

Requirement for additional (surgical) interventions (plate removal within 90 days) · Adults with fractures of the mandibular angle

Transbuccal miniplate combined with intraoral approach led to lower requirement for additional (surgical) interventions (plate removal… compared with intraoral approach alone; GRADE not reported.

1 finding from 1 review

Two miniplates (transbuccal approach) vs One miniplate plus two screws (intraoral approach at external oblique ridge)

Requirement for additional (surgical) interventions (plate removal) · Adults with fractures of the mandibular angle

Two miniplates (transbuccal approach) showed no clear difference in requirement for additional (surgical) interventions (plate removal) compared with one miniplate plus two screws (intraoral approach at external…; GRADE not reported.

1 finding from 1 review

Immediate implants (placed in a fresh extraction socket just after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Marginal bone level change · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate implants (placed in a fresh extraction socket just after… showed no clear difference in perimplant marginal bone level changes compared with delayed implants (placed at least 2 months after extraction, in…; GRADE not reported.

1 finding from 1 review