Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

84 questions · 84 findings · 12 reviews · Developmental, Psychosocial and Learning Problems

No studies found 35 · 41.7%GRADE not reported 0 · 0%Very low 29 · 34.5%Low 17 · 20.2%Moderate 3 · 3.6%High 0 · 0%

Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone

Expressive language (number of words; standard scores; MLUw; NDW; IPSyn; frequency of unique targets; % target talk) · children with Down syndrome aged between birth and six years
1 finding from 1 review

Intensive advocacy interventions for women who experience intimate partner abuse vs (Optimised) usual care

Overall abuse One study used a composite of two scales (12 items. Scale from 0 to 36) Other study used Composite Abuse Scale (CAS)i (30 items presented in a 6‐point format requiring respondents to answer 'never', 'only once', 'several times', 'mon... · women with intimate partner abuse
1 finding from 1 review

Neurohormones vs placebo

Adverse effects · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

It is very uncertain whether neurohormones changes adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

All‐cause morbidity · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… showed no clear difference in all‐cause morbidity (the most frequent event associated with the… compared with no supplementation or placebo (low certainty).

1 finding from 1 review