What do systematic reviews say?

Early vs standard initiation of kidney replacement therapy (KRT)

Early showed no clear difference in recovery of kidney function Patients free from KRT according to ITT… compared with standard initiation of kidney replacement therapy (KRT) (low certainty).

• Timing of kidney replacement therapy initiation for acute kidney injury 2022 · Cochrane Headline outcomes only
  RR 1.07 [0.94, 1.22]
  10 studies · 4717 participants
  Low

Early vs standard initiation of kidney replacement therapy (KRT)

Early leads to higher adverse events: hypophosphataemia compared with standard initiation of kidney replacement therapy (KRT) (high certainty).

• Timing of kidney replacement therapy initiation for acute kidney injury 2022 · Cochrane Headline outcomes only
  RR 1.8 [1.33, 2.44]
  1 study · 2927 participants
  High

Early vs standard initiation of kidney replacement therapy (KRT)

Early leads to higher adverse events: hypotension compared with standard initiation of kidney replacement therapy (KRT) (high certainty).

• Timing of kidney replacement therapy initiation for acute kidney injury 2022 · Cochrane Headline outcomes only
  RR 1.54 [1.29, 1.85]
  5 studies · 3864 participants
  High

Early vs standard initiation of kidney replacement therapy (KRT)

Early leads to higher adverse events: cardiac‐rhythm disorder compared with standard initiation of kidney replacement therapy (KRT) (high certainty).

• Timing of kidney replacement therapy initiation for acute kidney injury 2022 · Cochrane Headline outcomes only
  RR 1.35 [1.04, 1.75]
  6 studies · 4483 participants
  High

Early vs standard initiation of kidney replacement therapy (KRT)

Early showed no clear difference in adverse events: infection compared with standard initiation of kidney replacement therapy (KRT) (high certainty).

• Timing of kidney replacement therapy initiation for acute kidney injury 2022 · Cochrane Headline outcomes only
  RR 1.33 [1, 1.77]
  5 studies · 4252 participants
  High

Early vs standard initiation of kidney replacement therapy (KRT)

• Timing of kidney replacement therapy initiation for acute kidney injury 2022 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 4240 participants
  Moderate

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in mortality at day 30 compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.88 [0.81, 1.1]
  5 studies · 2402 participants
  Low

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in mortality after 30 days post‐randomisation compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.92 [0.8, 1.06]
  5 studies · 2759 participants
  Low

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in patients free of RRT after discontinuing CRRT compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 1.12 [0.91, 1.37]
  5 studies · 2402 participants
  Low
• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.98 [0.94, 1.01]
  3 studies · 988 participants
  Moderate

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive leads to higher adverse events: hypophosphataemia compared with less intensive continuous renal replacement therapy (CRRT) (high certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 1.21 [1.11, 1.31]
  1 study · 1441 participants
  High

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in mortality: patients with sepsis compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.94 [0.69, 1.27]
  5 studies · 966 participants
  Low

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in mortality: patients without sepsis compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.89 [0.69, 1.15]
  4 studies · 1216 participants
  Low

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive leads to lower mortality: patients with AKI related to cardiac or general surgery compared with less intensive continuous renal replacement therapy (CRRT) (high certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.73 [0.61, 0.88]
  2 studies · 531 participants
  High

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Intensive showed no clear difference in mortality: patients with AKI not related to surgery compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

• Intensity of continuous renal replacement therapy for acute kidney injury 2016 · Cochrane Headline outcomes only
  RR 0.94 [0.73, 1.2]
  3 studies · 1871 participants
  Low

Catheter guidewire exchange vs catheter removal and replacement

It is very uncertain whether catheter guidewire exchange changes cure: infection‐free survival compared with catheter removal and replacement (very low certainty).

• Interventions for treating catheter‐related bloodstream infections in people receiving maintenance haemodialysis 2022 · Cochrane Headline outcomes only
  HR 0.881 [0.43, 1.79]
  1 study · 678 participants
  Very low

Catheter guidewire exchange vs catheter removal and replacement

The review found no eligible studies for this question.

• Interventions for treating catheter‐related bloodstream infections in people receiving maintenance haemodialysis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Catheter guidewire exchange vs catheter removal and replacement

The review found no eligible studies for this question.

• Interventions for treating catheter‐related bloodstream infections in people receiving maintenance haemodialysis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Catheter guidewire exchange vs catheter removal and replacement

The review found no eligible studies for this question.

• Interventions for treating catheter‐related bloodstream infections in people receiving maintenance haemodialysis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Catheter guidewire exchange vs catheter removal and replacement

The review found no eligible studies for this question.

• Interventions for treating catheter‐related bloodstream infections in people receiving maintenance haemodialysis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

CVVHD vs CVVH or CVVHDF

The review found no eligible studies for this question.

• Non‐pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found