Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

30 questions · 33 findings · 4 reviews

No studies found 7 · 21.2%GRADE not reported 0 · 0%Very low 7 · 21.2%Low 10 · 30.3%Moderate 7 · 21.2%High 2 · 6.1%

Magnesium sulphate vs placebo (outcomes

Intraventricular haemorrhage, Papile grade 3/4 · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate probably leads to lower severe intraventricular haemorrhage (grade 3 or 4) (newborn/infant)** compared with placebo (outcomes (moderate certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Bronchopulmonary dysplasia/chronic lung disease · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in chronic lung disease/bronchopulmonary dysplasia (newborn/infant)** compared with placebo (outcomes (low certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Death (fetal, neonatal, or later (up to school age))** · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in death (fetal, neonatal, or later (up to school age))** compared with placebo (outcomes (low certainty).

1 finding from 1 review

Intervention not reported

Good neurological outcome · adults after cardiopulmonary resuscitation

The intervention may leads to higher good neurological outcome (low certainty).

1 finding from 1 review

Intervention not reported

Survival · adults after cardiopulmonary resuscitation

The intervention showed no clear difference in survival (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events – pneumonia · adults after cardiopulmonary resuscitation

The intervention showed no clear difference in adverse events – pneumonia (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events – hypokalaemia · adults after cardiopulmonary resuscitation

It is very uncertain whether the intervention changes adverse events – hypokalaemia (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events – arrhythmia · adults after cardiopulmonary resuscitation

The intervention may leads to higher adverse events – arrhythmia (low certainty).

1 finding from 1 review

Pre‐hospital cooling vs in‐hospital cooling

Adverse events ‐ re‐arrest after randomization · patients with out‐of‐hospital cardiac arrest

It is very uncertain whether pre‐hospital cooling changes adverse events ‐ re‐arrest after randomization compared with in‐hospital cooling (very low certainty).

1 finding from 1 review